2021-22 funded scientists recent research

2021-22 Grant Recipient Recent Research 

Sarah Baxter, M.D., Ph.D., University of Washington

• International Consensus for the Dosing of Corticosteroids in Childhood-Onset Systemic Lupus Erythematosus With Proliferative Lupus Nephritis
• Molecular diagnosis of childhood immune dysregulation, polyendocrinopathy, and enteropathy, and implications for clinical management

Maria Gutierrez-Arcelus, Ph.D., Boston Children’s Hospital

• Cellular deconstruction of inflamed synovium defines diverse inflammatory phenotypes in rheumatoid arthritis

Lauren Henderson, M.D., MMSc, Boston Children’s Hospital

Pui Y Lee, M.D., Ph.D., Boston Children’s Hospital

• Comprehensive analysis of ADA2 genetic variants and estimation of carrier frequency driven by a function-based approach

Ruth J. Napier, Ph.D., Oregon Health & Science University 

• The innate immune receptor Nlrp12 suppresses autoimmunity to the retina

Renuka Nayak, M.D., Ph.D., University of California, San Francisco

• Human gut bacterial metabolism drives Th17 activation and colitis

Michael Paley M.D., Ph.D., Washington University

• Glucocorticoids and B Cell Depleting Agents Substantially Impair Immunogenicity of mRNA Vaccines to SARS-CoV-2

Tam Quach, Ph.D., The Feinstein Institutes for Medical Research

• Context-dependent induction of autoimmunity by TNF signaling deficiency

Nisarg J. Shah, Ph.D., University of California, San Diego

• Immune-responsive biodegradable scaffolds for enhancing neutrophil regeneration

Hu Zeng, Ph.D., Mayo Clinic

• Antigen Specific Humoral and Cellular Immunity Following SARS-CoV-2 Vaccination in ANCA-Associated Vasculitis Patients Receiving B-Cell Depleting Therapy.

Shouan Zhu, Ph.D., Ohio University

• Sirt5 Deficiency Causes Posttranslational Protein Malonylation and Dysregulated Cellular Metabolism in Chondrocytes Under Obesity Conditions

• Obesity promotes lipid accumulation in mouse cartilage—A potential role of acetyl-CoA carboxylase (ACC) mediated chondrocyte de novo lipogenesis