Amr Sawalha, M.D.

Amr Sawalha, M.D.

2007-2008

Genetic Factors in Lupus
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Amr Sawalha, M.D.

University of Oklahoma Health Sciences Center
Oklahoma City, OK
CD40L overexpression in lupus T cells

Systemic lupus erythematosus (SLE or lupus) is a chronic, relapsing autoimmune disease that affects multiple organs including the skin, joints, lungs, kidneys and brain. The disease is at least nine times more common in females. There is evidence for both genetic and environmental factors implicated in the pathogenesis of lupus; however, the exact pathogenesis of the disease remains incompletely understood.

Using a mouse model, Dr. Sawalha will study a specific gene that is over expressed in the T regulatory white cells of female but not male mice. The goal of these studies is to provide new insights into mechanisms causing lupus, and identify new approaches to the treatment of this sometimes fatal disease.

ANRF
Article Author
Arthritis National Research Foundation
arthritisresearch@curearthritis.org

The Arthritis National Research Foundation's mission is to provide initial research funding to brilliant, investigative scientists with new ideas to cure arthritis and related autoimmune diseases. Writing articles about the patients affected and the science being done to find a cure shows why we need to come together to #CureArthritis!

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