Author: ANRF

2008-2009 Mouse Model Mimics Human RA in Late Stages Candace Cham, Ph.D. Stanford University Stanford, CA New Humanized Mouse Model of Chronic Rheumatoid Arthritis in Humans In rheumatoid arthritis (RA), the immune system attacks and damages the individual’s own joints. RA is characterized by episodes of acute inflammation,...

2009-2010 Cytokine Study may lead to New Therapy Yang "Benny" Yi, Ph.D. New York University School of Medicine New York, NY Studies of the roles of IL-23 and IL-22 in arthritogenic Th17 cell responses and the pathogenesis of autoimmune arthritis The immune system mounts protective responses to clear invading...

2009-2010 Molecular Pathways in Lupus Studied Maida Wong, M.D. UCLA Los Angeles, CA James Klinenberg Scholar Programmed death-1-Programmed death-1 ligand (PD-1-PDL-1) pathway in the New Zealand Black x New Zealand white murine model: a molecular approach Dr. Wong’s research will study the molecular pathway of lupus using a mouse model....

2009-2010 Th17 Cell Characteristics may have Implications for all Autoimmune Diseases Sujata Sarkar, M.D. University of Arizona Tucson, AZ Characterization of pathogenic Th17 responses in collagen induced arthritis The question, “Why do we get autoimmune diseases like rheumatoid arthritis?” remains to be answered. All autoimmune disorders is associated...

2009-2010 The Role of Neutrophils in Inflammatory Arthritis Peter Nigrovic, M.D. Children’s Hospital Boston Boston, MA John Vaughan Scholar A novel modulator of neutrophil function in inflammatory arthritis Neutrophils are immune cells that migrate into the joint cavity during inflammatory arthritis. Studies in mice confirm that neutrophils are absolutely...

2009-2010 Specific Cytokine Identified as Risk Factor for Lupus Timothy Niewold, M.D. University of Chicago Chicago, IL Eng Tan Scholar Genetic Regulation of Interferon Alpha Human Lupus Lupus is a complex disease in which the body's immune system attacks its own tissues and organ systems. For the most part,...

2009-2010 Targeting Osteoarthritis Shigeru Miyaki, Ph.D. The Scripps Research Institute La Jolla, CA The role of cartilage-specific microRNA in osteoarthritis pathogenesis Osteoarthritis (OA), the most prevalent, age-related joint disease, is characterized by degradation in joint cartilage. Molecular mechanisms that govern the development and maintenance of cartilage are being...

2009-2010 Hormone May Play Role in Controlling Lupus Elaine Lourenco, Ph.D. UCLA Los Angeles, CA Josephine Rich Memorial Fellow The Influence of Leptin on Regulatory T cells in Murine Lupus The immune system is made of tissues and cells that have the task to protect against disease-causing pathogens or tumors....

2009-2010 Making a New Meniscus Mai Thuy Lam, Ph.D. Stanford University Stanford, CA Ethelmae Haldan Grant for Innovative Research in Osteoarthritis Multi-factor knee meniscus tissue engineering Osteoarthritis (OA) is the most common type of arthritis, and is often viewed as age-related, “wear and tear” degeneration of the cartilage lining the...

2009-2010 Finding the Genes that Cause Lupus Courtney Gray-McGuire, Ph.D. Oklahoma Medical Research Foundation Oklahoma City, OK Genes for early systemic lupus erythematosus autoimmunity in African Americans Systemic lupus erythematosus (SLE or lupus) is a complex disease with a variety of clinical manifestations, many of which can be debilitating...