ANRF Blog

Identification of biomarkers may mean earlier diagnosis Lisa Peterson, Ph.D. National Jewish Health Denver, CO Role of autoantibodies in pulmonary manifestations of inflammatory arthritis Rheumatoid arthritis (RA) is a systemic inflammatory disease affecting approximately 1% of the general population leading to progressive arthritis and manifestations outside of the joints, including...

Factors that may provide targets to stop OA progression Andreia Ionescu, Ph.D. Harvard Medical School Boston, MA The role of FoxA factors in the onset and development of Osteoarthritis Osteoarthritis is a degenerative disease of joint cartilage and at present there is no therapy available (other than joint replacement)...

Selectively targeting cells in RA treatment Gonghua Huang, Ph.D. St. Jude Children’s Research Hospital Memphis, TN p38α signaling and TH17 cell differentiation and function in autoimmune arthritis Rheumatoid arthritis (RA) and its mouse model, collagen-induced arthritis (CIA), are characterized by systemic and synovial tissue inflammation, beginning in the joints. TH17...

Lupus: How does the body produce autoantibodies? Stephen Gauld, Ph.D. Medical College of Wisconsin Milwaukee, WI Regulatory and Follicular Helper T cells in Lupus Systemic lupus erythematosus (lupus) is a chronic autoimmune disease driven by the production of autoantibodies, antibodies that attack self-tissues. The mechanisms that drive autoantibody production...

Mechanisms in Lupus: Defining the signaling pathway Julie Zikherman, M.D. University of California San Francisco, CA Investigating how distinct alleles of the phosphatase CD45 differentially regulate B cell tolerance and systemic autoimmunity Systemic lupus erythematosus (lupus) is an autoimmune disease that can result in such devastating outcomes as renal failure...

Hyaluronan loss may be one cause of Osteoarthritis Yingcui Li, Ph.D. University of Connecticut Health Center Farmington, Connecticut Genetic Analysis of Hyaluronan Function in Osteoarthritis Osteoarthritis (OA) results from damage and degeneration of joint cartilage. Maintenance of healthy joints depends on preserving the normal balance of cartilage breakdown and...

Testing a Novel Way to Treat Arthritis Hye-Jung Kim, Ph.D. Dana-Farber Cancer Institute Boston, Massachusetts CD8+ Treg suppression of collagen-induced arthritis Autoimmune diseases, including Rheumatoid Arthritis (RA), occur when the immune system mistakenly attacks the body’s own tissues. This complex system of cells and antibodies normally destroys “invaders” such as...

Gender-specific risk factors in RA Jawaheer, Damini, Ph.D. Children’s Hospital Oakland Research Institute Oakland, CA Gender-Specific Genetic Associations in Rheumatoid Arthritis Rheumatoid arthritis (RA) affects approximately 1% of the adult world population, and contributes significantly to the global burden of disease. Although gender is the strongest known risk factor for...

Juvenile Arthritis: Studying what may predispose children to JIA Altan Ercan, Ph.D. Brigham and Women’s Hospital Boston, MA The Kelly Award for Juvenile Arthritis Research: Gender-dependent regulation of IgG glycosylation in Juvenile and Adult Arthritis Immunoglobulin G (IgG) is an important contributor to inflammation within the joint. Its interaction with other...

Increasing RA Drug Efficiency: A Clinical Project Massimo Bottini, Ph.D. Sanford-Burnham Medical Research Institute La Jolla, California Nanosystem for targeting Treg in vivo Regulatory T cells (Treg) are an immune cell population that plays an active role in protecting humans against rheumatoid arthritis. The delivery of drugs specifically to Treg...