ANRF Blog

2002-2003 Interleukin-4 Potentiates Peripheral Deletion of Autoreactive Th1 Cells in Proteoglycan-Induced Arthritis Jian Zhang, M.D. Rush-Presbyterian – St. Luke’s Medical Center Chicago, IL Dr. Zhang is studying the mechanism of treating RA with a cytokine called Interleukin-4, which is thought to retard the disease development by inducing apoptosis...

2002-2003 The role of DRAK2, a lymphoid-enriched apoptotic nuclear DAP-like kinase, in T cell activation and autoimmunity Craig Walsh, Ph.D. University of California Irvine, CA Dr. Walsh’s study is aimed at understanding the basic mechanisms that prevent inappropriate lymphocyte activation in autoimmune diseases, such as rheumatoid arthritis. He...

2002-2003 Inducer-specific TNF-alpha gene regulation in T lymphocytesAlla Tsytsykova, Ph.D. The Center for Blood Research (affiliated with Harvard University) Boston, MA This is the second year Dr. Tsytsykova has received funding for her work from ANRF. She is continuing her work studying the process by which the...

2002-2003 Role of protein kinase R in TNF-alpha production Kristine Phillips, M.D., Ph.D. Brigham and Women’s Hospital (affiliated with Harvard Medical School) Boston, MA Dr. Phillips’ study is evaluating how different levels of TNR-alpha protein are produced. Treatment of arthritis has been revolutionized by the use of biologic...

2002-2003 The Role of p21 in regulating IL-6 and MMP in RA Harris Perlman, Ph.D. Saint Louis University St Louis, MO Dr. Perlman has identified a gene, p21 that prevents growth and secretion of pro-inflammatory molecules in rheumatoid arthritis. He is studying the pathways of this gene, trying...

2002-2003 Prevention and treatment of Collagen-Induced Arthritis by adoptive cellular gene therapy Alenka Levicnik, M.D. Stanford University School of Medicine Stanford, CT Dr. Levicknik is studying a mouse model of rheumatoid arthritis (RA) similar to human RA. She is attempting a new treatment regimen, adoptive cellular gene therapy....

2002-2003 Characterization of Autoantibody-Reactive T Lymphocytes in Murine Systemic Lupus Erythematosus (SLE) Antonio La Cava, M.D., Ph.D. UCLA Los Angeles, CA Dr. La Cava will study the characteristics of the cells responsible for the regulation of immune responses in a mouse model that spontaneously develops lupus. The results...

2002-2003 Identification of T cell epitopes that are relevant in the pathogenesis and progression of pediatric SLE. Francesca Giannoni, Ph.D. University of California-San Diego San Diego, CA Dr. Giannoni’s project consists of the identification and characterization of the self-proteins thought to cause inflammation in children with lupus. They...

2002-2003 Role of NFFAT Proteins in DC154 Gene Regulation and Lupus Randy Cron, M.D., Ph.D. The Children’s Hospital of Philadelphia – University of Pennsylvania Philadelphia, PA Recent findings show that a protein, CD154, is abnormally expressed on the surface of certain white cells of lupus patients. While a...

2002-2003 Elucidating the Mechanism of Receptor Editing Cynthia Benedict, Ph.D. Princeton University Princeton, NJ How the Ig Heavy or Light Chain may be Rearranged Secondarily to Avoid Autoreactivity. Dr. Benedict’s study centers on the effects of anti-DNA antibodies in systemic lupus erythematosus (SLE or lupus). She will examine genetically...