ANRF Blog

2002-2003 Elucidating the Mechanism of Receptor Editing Cynthia Benedict, Ph.D. Princeton University Princeton, NJ How the Ig Heavy or Light Chain may be Rearranged Secondarily to Avoid Autoreactivity. Dr. Benedict’s study centers on the effects of anti-DNA antibodies in systemic lupus erythematosus (SLE or lupus). She will examine genetically...

2002-2003 Autoantibodies to GPI in Rheumatoid Arthritis Pathogenesis. Monica Schaller, Ph.D. The Scripps Research Institute La Jolla, CA Dr. Schaller is studying an enzyme present in all cells of the human body, GPI (glucose-6-phosphate isomerase). Preliminary studies indicate that anti-GPI antibodies, found in higher levels in the blood...

2003-2004 Generation of antigen-specific T regulatory cells in TCR transgenic mice to prevent the collagen-induced arthritis Song Guo Zheng, M.D. University of Southern CaliforniaLos Angeles, CA The objective of Dr. Zheng’s project was to develop therapy for RA that is effective, but without significant toxicity. RA...

2003-2004 Fine mapping of the significantly linked SLE susceptibility loci at 1q23-24 in multiethnic groups Hui Wu, M.D. UCLA School of Medicine Los Angeles, CA Systemic Lupus Erythematosus (SLE or lupus) occurs more frequently in families of SLE than in the general population. Dr. Wu observed strong...

2003-2004 Autoantibodies to GPI in human inflammatory arthritides Monica M. Schaller, Ph.D. The Scripps Research Institute La Jolla, CA Dr. Schaller enjoys the distinction of receiving an ANRF grant award in two consecutive years. This is a continuation of her study from the previous year, seeking to...

2003-2004 Lipid Antigen Presentation by Endothelial Cells: A Molecular Model of Kawasaki Disease David S. Leslie, M.D. Brigham & Women’s Hospital Boston, MA Kawasaki disease (KD) is the leading cause of acquired heart disease among children in the U.S., causing damage to the blood vessels, including those that...

2003-2004 Modulation of Fibrosis by Statins in Murine Model of Scleroderma Gabriella Lakos, M.D., Ph.D. University of Illinois at Chicago Chicago, IL Scleroderma is a chronic, progressive multi-system connective tissue disorder of unknown etiology with no effective treatment. Five-year mortality approaches 40%, largely due to scarring of...

2003-2004 Role of TLR 3 in Autoimmunity to RNA Binding Proteins Eric Greidinger, M.D. So. Florida VA Foundation, University of Miami Miami, FL Many forms of arthritis are autoimmune diseases because they are associated with immune responses directed against self-proteins. A feature of many of the commonly...

2003-2004 Lifetime Patterns of Body Mass and Quantitative Measure of Osteoarthritis Risk Dana Duren, Ph.D. Wright State University Dayton, OH Adulthood obesity is known to be associated with risk for osteoarthritis (OA). Yet, it is currently unknown what influence childhood or early adulthood weight patterns may have...

2003-2004 Role of NF-kB2/p100 processing in BAFF expression Emmanuel Dejardin, Ph.D. La Jolla Institute for Allergy and Immunology San Diego, CA Dr. Dejardin’s identified molecular pathways that lead to the activation of two subsets of genes. One pathway is implicated in the expression of pro-inflammatory genes. ...