ANRF Blog

2003-2004 Cav1 (L-type) calcium channels as target for manipulation CD4+ T cell response Abdallah Badou, Ph.D. Yale University School of Medicine-Howard Hughes Medical Institute New Haven, CT Dr. Badou studied how T-cells are activated in RA. These T-cells orchestrate getting the immune system involved in RA. Badou...

2003-2004 Gender Effect on Arthritis Phenotypes in a Murine Model of Rheumatoid Arthritis Vyacheslav Adarichev, Ph.D. Rush-Presbyterian-St. Luke’s Medical Center Chicago, IL Dr. Adarichev is the 2003 recipient of The Sontag Foundation Fellowship of the Arthritis National Research Foundation. This is the third such special fellowship award...

2004-2005 Mechanisms of Action of the Transcription Factor T-bet in Dendritic Cells Jingsong Wang, M.D. Harvard School of Public Health Boston, MA T helper lymphocytes are of two different types, called T helper 1 and T helper 2. They are defined in that manner because they make...

2004-2005 Transcriptional regulation of chondrogenesis via histone modifications Masanao Tsuda, Ph.D. The Scripps Research Institute La Jolla, CA Osteoarthritis (OA) is the disease characterized by progressive joint destruction without regeneration of new cartilage. Regeneration of cartilage relies on appropriate control of chondrocyte development, whose process is tightly regulated...

2004-2005 Effects of BAFF and APRIL Blockade on B cells in Murine Antiphospholipid Syndrome Meera Ramanujam, Ph.D. Columbia University New York, NY Lupus is an autoimmune disease in which B lymphocytes make autoantibodies that deposit in the kidney and may lead to kidney damage. Another major complication...

2004-2005 Plasmacytoid dendritic cell production of IFN-alpha in lupus prone mice Susan Kovats, Ph.D. Beckman Research Institute/City of Hope Duarte, CA Dr. Kovats will be working with former ANRF grant recipient, Chaim Jacob, M.D., Ph.D., of the University of Southern California to study the role of the cytokines,...

2004-2005 Role of AHNAK in calcium signaling in T lymphocytes Koichi Kobayashi, M.D., Ph.D. Yale University School of Medicine New Haven, CT The most recently developed treatments for autoimmune diseases such as rheumatoid arthritis or lupus are based on regulation of an uncontrolled immune system by immunosuppressive drugs....

2004-2005 The role of estrogen receptors in B cell mediated autoreactivity Christine Grimaldi, Ph.D. Columbia University New York, NY Dr. Grimaldi’s study focuses on systemic lupus erythematosus (SLE), an autoimmune disease caused by the production of autoantibodies that mediate tissue damage in target organs, such as the kidney....

2004-2005 Effect of TNF inhibitors on left ventricular structure and function in patients with Rheumatoid Arthritis Jon Giles, M.D. The Johns Hopkins University School of Medicine Baltimore, MD Dr. Giles is the 2004 recipient of the Sontag Foundation Fellowship of the Arthritis National Research Foundation. This is...

2004-2005 Peptidylarginine Deiminase IV: Enzymology of a Rheumatoid Arthritis Susceptibility Gene Product Walter Fast, Ph.D. University of Texas at Austin Austin, TX Rheumatoid arthritis is a chronic inflammatory condition affecting almost 1% of the world’s population. The etiology of this complex disease is still unknown. However,...