ANRF Blog

2004-2005 Mechanisms of Action of the Transcription Factor T-bet in Dendritic Cells Jingsong Wang, M.D. Harvard School of Public Health Boston, MA T helper lymphocytes are of two different types, called T helper 1 and T helper 2. They are defined in that manner because they make...

2004-2005 Transcriptional regulation of chondrogenesis via histone modifications Masanao Tsuda, Ph.D. The Scripps Research Institute La Jolla, CA Osteoarthritis (OA) is the disease characterized by progressive joint destruction without regeneration of new cartilage. Regeneration of cartilage relies on appropriate control of chondrocyte development, whose process is tightly regulated...

2004-2005 Effects of BAFF and APRIL Blockade on B cells in Murine Antiphospholipid Syndrome Meera Ramanujam, Ph.D. Columbia University New York, NY Lupus is an autoimmune disease in which B lymphocytes make autoantibodies that deposit in the kidney and may lead to kidney damage. Another major complication...

2004-2005 Plasmacytoid dendritic cell production of IFN-alpha in lupus prone mice Susan Kovats, Ph.D. Beckman Research Institute/City of Hope Duarte, CA Dr. Kovats will be working with former ANRF grant recipient, Chaim Jacob, M.D., Ph.D., of the University of Southern California to study the role of the cytokines,...

2004-2005 Role of AHNAK in calcium signaling in T lymphocytes Koichi Kobayashi, M.D., Ph.D. Yale University School of Medicine New Haven, CT The most recently developed treatments for autoimmune diseases such as rheumatoid arthritis or lupus are based on regulation of an uncontrolled immune system by immunosuppressive drugs....

2004-2005 The role of estrogen receptors in B cell mediated autoreactivity Christine Grimaldi, Ph.D. Columbia University New York, NY Dr. Grimaldi’s study focuses on systemic lupus erythematosus (SLE), an autoimmune disease caused by the production of autoantibodies that mediate tissue damage in target organs, such as the kidney....

2004-2005 Effect of TNF inhibitors on left ventricular structure and function in patients with Rheumatoid Arthritis Jon Giles, M.D. The Johns Hopkins University School of Medicine Baltimore, MD Dr. Giles is the 2004 recipient of the Sontag Foundation Fellowship of the Arthritis National Research Foundation. This is...

2004-2005 Peptidylarginine Deiminase IV: Enzymology of a Rheumatoid Arthritis Susceptibility Gene Product Walter Fast, Ph.D. University of Texas at Austin Austin, TX Rheumatoid arthritis is a chronic inflammatory condition affecting almost 1% of the world’s population. The etiology of this complex disease is still unknown. However,...

2004-2005 Role of Chemokines and matrix metalloproteinases in resolution vs. fibrosis in a murine model of granulomatous experimental autoimmune thryoiditis (G-EAT): implications for pathology and treatment Kemin Chen, M.D., Ph.D. University of Missouri-Columbia School of Medicine Columbia, MD Fibrosis, or scarring, is a relatively common complication in rheumatic...

2004-2005 The roles of TIMP-1 in cartilage degradation and repair after load-induced injury Christopher Chen, Ph.D. The Hospital for Special Surgery New York, NY Osteoarthritis, the leading cause for disability in the U.S., is the object of Dr. Chen’s study. OA is the breakdown of cartilage which...