ANRF Blog

2004-2005 Role of Chemokines and matrix metalloproteinases in resolution vs. fibrosis in a murine model of granulomatous experimental autoimmune thryoiditis (G-EAT): implications for pathology and treatment Kemin Chen, M.D., Ph.D. University of Missouri-Columbia School of Medicine Columbia, MD Fibrosis, or scarring, is a relatively common complication in rheumatic...

2004-2005 The roles of TIMP-1 in cartilage degradation and repair after load-induced injury Christopher Chen, Ph.D. The Hospital for Special Surgery New York, NY Osteoarthritis, the leading cause for disability in the U.S., is the object of Dr. Chen’s study. OA is the breakdown of cartilage which...

2004-2005 Potassium Channels in Lymphocytes: Therapeutic Targets for Immunomodulation in Rheumatoid Arthritis Christine Beeton, Ph.D. University of California Irvine, CA Under normal conditions, white blood cells such as T lymphocytes, protect the body against disease-causing mechanisms. In autoimmune diseases such as rheumatoid arthritis (RA), the body attacks...

2005-2006 Beyond TNF: A Newly Discovered Cytokine may provide new target for RA Therapy Christopher Benedict, Ph.D. La Jolla Institute for Allergy and Immunology San Diego, CA Tumor necrosis factor (TNF) is a cytokine produced by the body’s immune cells that fuels the process of inflammation in rheumatoid...

2005-2006 Molecular Pathways to Safer Autoimmune Treatments Koichi Kobayashi, M.D., Ph.D. Harvard University Dana-Farber Cancer Institute Boston, MA Role of AHNAK in calcium signaling in T lymphocytes Current treatments for autoimmune diseases such as rheumatoid arthritis or lupus are based on regulation of an uncontrolled immune system by immunosuppressive...

2005-2006 Increased Estrogen May Alter Immune Response Christine Grimaldi, Ph.D. Columbia University Department of Medicine New York, NY The role of estrogen receptors in B cell autoreactivity Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the production of autoantibodies that may cause tissue damage of...

2005-2006 RA Gene Susceptibility Study Walter Fast, Ph.D. The University of Texas at Austin Austin, TX Peptidylarginine Deiminase 4: Enzymology of a Rheumatoid Arthritis Susceptibility Gene Product Rheumatoid arthritis is a chronic inflammatory condition affecting almost 1% of the world’s population. The cause of this complex disease is still...

2005-2006 Reversing Fibrosis Kemin Chen, M.D., Ph.D. University of Missouri-Columbia Columbia, MO Role of Chemokines and matrix metalloproteinases in resolution vs fibrosis in a murine model of granulomatous experimental autoimmune thyroiditis (G-EAT): implications for pathology and treatment Fibrosis is the cycle of damage-healing-scarring-damage, etc. in inflammatory disease. The functions...

2005-2006 Alternative to Immunosuppressive Drugs Song Guo Zheng, M.D. University of Southern California Los Angeles, CA Effects of TGF-B on both CD4+ and CD8+ cells are required for optimal generation and function of regulatory cells Certain cells that respond to self tissues or organs exist in normal humans; however,...

2005-2006 Novel Imaging Technique Xueding Wang, Ph.D. University of Michigan Ann Arbor, MI Photoacoustic tomography of inflammatory arthritis The 2005-2006 Sontag Foundation Fellowship award recipient, Xueding Wang, Ph.D., developed a new technique using laser technology to provide images of soft tissues such as joints affected by arthritis. He will...