ANRF Blog

2004-2005 Potassium Channels in Lymphocytes: Therapeutic Targets for Immunomodulation in Rheumatoid Arthritis Christine Beeton, Ph.D. University of California Irvine, CA Under normal conditions, white blood cells such as T lymphocytes, protect the body against disease-causing mechanisms. In autoimmune diseases such as rheumatoid arthritis (RA), the body attacks...

2005-2006 Beyond TNF: A Newly Discovered Cytokine may provide new target for RA Therapy Christopher Benedict, Ph.D. La Jolla Institute for Allergy and Immunology San Diego, CA Tumor necrosis factor (TNF) is a cytokine produced by the body’s immune cells that fuels the process of inflammation in rheumatoid...

2005-2006 Molecular Pathways to Safer Autoimmune Treatments Koichi Kobayashi, M.D., Ph.D. Harvard University Dana-Farber Cancer Institute Boston, MA Role of AHNAK in calcium signaling in T lymphocytes Current treatments for autoimmune diseases such as rheumatoid arthritis or lupus are based on regulation of an uncontrolled immune system by immunosuppressive...

2005-2006 Increased Estrogen May Alter Immune Response Christine Grimaldi, Ph.D. Columbia University Department of Medicine New York, NY The role of estrogen receptors in B cell autoreactivity Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the production of autoantibodies that may cause tissue damage of...

2005-2006 RA Gene Susceptibility Study Walter Fast, Ph.D. The University of Texas at Austin Austin, TX Peptidylarginine Deiminase 4: Enzymology of a Rheumatoid Arthritis Susceptibility Gene Product Rheumatoid arthritis is a chronic inflammatory condition affecting almost 1% of the world’s population. The cause of this complex disease is still...

2005-2006 Reversing Fibrosis Kemin Chen, M.D., Ph.D. University of Missouri-Columbia Columbia, MO Role of Chemokines and matrix metalloproteinases in resolution vs fibrosis in a murine model of granulomatous experimental autoimmune thyroiditis (G-EAT): implications for pathology and treatment Fibrosis is the cycle of damage-healing-scarring-damage, etc. in inflammatory disease. The functions...

2005-2006 Alternative to Immunosuppressive Drugs Song Guo Zheng, M.D. University of Southern California Los Angeles, CA Effects of TGF-B on both CD4+ and CD8+ cells are required for optimal generation and function of regulatory cells Certain cells that respond to self tissues or organs exist in normal humans; however,...

2005-2006 Novel Imaging Technique Xueding Wang, Ph.D. University of Michigan Ann Arbor, MI Photoacoustic tomography of inflammatory arthritis The 2005-2006 Sontag Foundation Fellowship award recipient, Xueding Wang, Ph.D., developed a new technique using laser technology to provide images of soft tissues such as joints affected by arthritis. He will...

2005-2006 Preventing Bone Loss in RA Nicole Cherie Walsh, Ph.D. Beth Israel Deaconess Medical Center, Harvard Institute of Medicine Boston, MA The role of T cells in the pathogenesis of focal articular bone loss in inflammatory arthritis The structural integrity of bone is maintained by the coordinated actions of...

2005-2006 Cartilage Regeneration in OA Anna Spagnoli, M.D. Vanderbilt University Medical Center Memphis, TN Role of insulin-like growth factor (IGF-I) in mesenchymal stem cell cartilage regeneration In industrialized countries, osteoarthritis affects over one-third of the adult population. Since cartilage is unable to repair itself, treatments for osteoarthritis primarily cover...