ANRF News And Stories

2005-2006 The Role of B Cells in RA Taras Lyubchenko, Ph.D. University of Colorado Health Sciences Center Denver, CO Role of complement receptor 2 (CR2/CD21) in B cell receptor signal transduction Understanding the mechanisms underlying activation of antibody-producing B cells is particularly important in autoimmune diseases such as...

2005-2006 Gene Therapy for Lupus Martin Kriegel, M.D. Yale University School of Medicine New Haven, CT T Cell-specific Deletion of GRAIL – the gene related to anergy in lymphocytes One key mechanism to preserve normal immune response – called T cell anergy – is disturbed in SLE patients and...

2005-2006 Proteins that may cause RA Myung-Shin Jeon, Ph.D. La Jolla Institute for Allergy and Immunology San Diego, CA c-Cbl in the development of autoimmune arthritis T cells are the critical components in the initiation and the maintenance of autoimmune diseases, such as rheumatoid arthritis. Dr. Myung-Shin Jeon will...

2005-2006 Using a New Genetic Tool Hongbo Chi, Ph.D. Yale University School of Medicine New Haven, CT S1P1 and regulation of autoimmune disease T lymphocytes, a type of white blood cell, play a central role in the regulation of immune responses against infection. The function of T lymphocytes is...

2005-2006 New Therapeutic Target for Lupus David Cauvi, Ph.D. The Scripps Research Institute La Jolla, CA Decay accelerating factor and systemic autoimmunity Systemic lupus erythematosus (SLE or lupus) is a devastating chronic autoimmune disease affecting multiple organ systems and characterized by a broad array of antibodies. Dr. David Cauvi’s...

2006-2007 Alternative to Immunosuppressive Drugs Song Guo Zheng, M.D. University of Southern California Los Angeles, CA Effects of TGF-beta on both CD4+ and CD8+ cells are required for optimal generation and function of regulatory T cells Certain cells that respond to self tissues or organs exist in normal humans;...

2006-2007 Preventing Bone Loss in RA Nicole Cherie Walsh, Ph.D. Beth Israel Deaconess Medical Center, Harvard Institute of Medicine Boston, MA The role of T cells in the pathogenesis of focal articular bone loss in inflammatory arthritis The structural integrity of bone is maintained by the coordinated actions of...

2006-2007 Cartilage Regeneration in OA Anna Spagnoli, M.D. Vanderbilt University Medical Center Memphis, TN Role of Insulin-like Growth Factor-I (IGF-I) in Mesenchymal Stem Cell Cartilage Regeneration In industrialized countries, osteoarthritis affects over one-third of the adult population. Since cartilage is unable to repair itself, treatments for osteoarthritis primarily cover...

2006-2007 Understanding the Immune System Adam Mor, M.D. New York University School of Medicine, Hospital for Joint Diseases New York, NY Ras signaling in autoimmune T cells: Mechanism of Ras activation on the Golgi apparatus The immune system is designed to protect us from infection, but when its regulation...

2006-2007 The Role of B Cells in RA Taras Lyubchenko, Ph.D. University of Colorado Health Sciences Center Denver, CO Role of Complement Receptor 2 (CR2/CD21) in B cell receptor signal transduction Understanding the mechanisms underlying activation of antibody-producing B cells is particularly important in autoimmune diseases such as rheumatoid...