ANRF News And Stories

2006-2007 Using a New Genetic Tool Hongbo Chi, Ph.D. Yale University School of Medicine New Haven, CT S1P Receptors and Regulation of Immunity and Autoimmune Disease T lymphocytes, a type of white blood cell, play a central role in the regulation of immune responses against infection. The function of...

2006-2007 Cartilage Regeneration Study Li Zeng, Ph.D. Tufts University School of Medicine Boston, MA Nkx3.2 nuclear localization and cartilage formation Arthritis is a widespread, debilitating disease in which the joint cartilage slowly disintegrates. One of the possible remedies for this disease is to regenerate cartilage and transplant the regenerated...

2006-2007 Autoimmune Disease Inhibited by T Regulatory Cells Shiguang Yu, Ph.D. University of Missouri Columbia, MO Mechanisms by which CD4 and CD25 Regulatory T Cells inhibit Autoimmune Diseases in the Absence of B Cells Autoimmune diseases arise when the immune system reacts against self tissues or organs. Low activity...

2006-2007 Assessing RA Risk at Genetic Level Hui Wu, M.D. University of California Los Angeles, CA RANK Ligand Polymorphisms Contributing to Early Onset of RA Genetic risk factors for RA susceptibility and severity have been widely studied. The main goal of Dr. Wu’s project is to map the gene...

2006-2007 Understanding OA Hee-Jeong Im Sampen, Ph.D. Rush University Medical Center Chicago, IL IL-1beta altered SUMO pathway in the Pathogenesis of Osteoarthritis Osteoarthritis is a disease that causes significant pain and disability. Given the increasing prevalence of OA in the aging population around the world, its public health impact...

2006-2007 Insuring B Cell Tolerance Julie Lang, Ph.D. University of Colorado Health Sciences Center Denver, CO The role of CR2 in central and peripheral tolerance A subset of white blood cells, known as B lymphocytes, is responsible for generating antibodies during an immune response to infection. In normal individuals,...

2006-2007 A Lupus Therapy without Toxicity Hee Kap Kang, Ph.D. Northwestern University Chicago, IL Mechanism of Low-dose Tolerance with Nucleosomal Peptides in Lupus Dr. Kang has developed a therapy to repair a cell defect which may cause lupus. To test this therapy, Dr. Kang’s lab is studying the effects...

2006-2007 Defining Genetics of RA in African Americans Damini Jawaheer, Ph.D. UCLA Semel Institute for Neuroscience and Human Behavior Los Angeles, CA Variations in Candidate Gene Polymorphisms Associated with RA in African Americans This is a genetic study of African Americans with RA. Dr. Jawaheer will test and map...

2006-2007 DRAK2: Target for New Therapy Martina Gatzka, M.D. University of California Irvine, CA Modulation of central and peripheral immunological tolerance by DRAK2, a negative regulator of lymphocyte signaling When T lymphocytes, a type of white blood cell, cannot distinguish between self and non-self tissues, they contribute to inflammation...

2006-2007 Arthritis and Growth in Children Hulya Bukulmez, M.D. Case Western Reserve University Cleveland, OH Does disruption of the C-type natriuretic peptide (CNP) signaling pathway cause cartilage degradation and growth retardation in juvenile rheumatoid arthritis? Dr. Bukulmez is studying the effect of chronic arthritis on a child’s growth. The...