ANRF News And Stories

2007-2008 Understanding Inflammatory Progression in RA Mei Chen, M.D., Ph.D. Brigham & Women’s Hospital Boston, MA The Mechanisms of LTB4-induced Migration and Invasion in Fibroblast-like Synoviocytes (FLS) Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that primarily targets synovial tissues, which forms the joint lining and produces lubricating...

2008-2009 Osteoarthritis: Targeting a Protein in Cartilage Damage Noboru Taniguchi, M.D., Ph.D. The Scripps Research Institute La Jolla, CA A novel chromatin protein involved in cartilage homeostasis and osteoarthritis Osteoarthritis is the most prevalent joint disease. In 1990 approximately 40 million Americans were affected and this number is predicted...

2008-2009 New RA Therapy Explored: IL-27 Shiva Shahrara, Ph.D. Northwestern University Chicago, IL Recipient of The Sontag Foundation Fellow of the ANRF The Role of IL-27 in Experimental Arthritis IL-17 is a pro-inflammatory mediator that is expressed in rheumatoid arthritis (RA) joint tissue and joint fluid. IL-17 is...

2008-2009 Role of T Cells in Arthritis Christina Roark, Ph.D. National Jewish Medical and Research Center Denver, CO The Regulatory Role of Th-17 Like ?d T Cells in Collagen-Induced Arthritis The importance of the cytokine, IL-17, in autoimmune diseases has led to numerous studies investigating the development of the...

2008-2009 Genetic Study of Defective Tolerance in Lupus Ziaur Rahman, M.D., Ph.D. Thomas Jefferson University Philadelphia, PA Impact of lupus susceptibility loci on peripheral B cell tolerance Virginia L. Riddle Memorial Fellowship of the ANRF The body has an efficient and complex system known as the immune system that develops...

2008-2009 Specific Cytokine Identified as Risk Factor for Lupus Timothy Niewold, M.D. University of Chicago Chicago, IL Genetic Determinants of Lupus Risk Acting Via the Interferon Alpha Pathway Lupus is a complex disease in which the body's immune system attacks its own tissues and organ systems. For the...

2008-2009 Hormone May Play Role in Controlling Lupus Elaine Lourenco, Ph.D. University of California, Los Angeles Los Angeles, CA The Influence of Leptin on Regulatory T Cells in Murine Lupus The immune system is made of tissues and cells that have the task to protect against disease-causing pathogens or...

2008-2009 Important Osteoarthritis Study Wins Grant for Innovative Science Chuanju Liu, Ph.D. New York University New York, NY Recipient: The Ethelmae Haldan Grant for Innovative Science in Osteoarthritis GEP: A Novel Chondrogenic Growth Factor and Target in Arthritis Arthritis is a degenerative joint disease, occurring primarily in the senior population,...

2008-2009 A Clue to Bone Loss in Rheumatoid Arthritis Sougata Karmakar, Ph.D. University of Massachusetts Worcester, MA The role of BMP3 in the pathogenesis of focal articular bone loss in inflammatory arthritis Rheumatoid arthritis (RA) is a chronic, debilitating disease that affects the joints in patients and may result...

2008-2009 Finding New Genes that Control Inflammatory Arthritis Alyssa Johnsen, M.D., Ph.D. Joslin Diabetes Center Boston, MA Identification of Genes Governing Susceptibility to Inflammatory Arthritis Rheumatoid arthritis (RA) is caused by a complex set of environmental and genetic factors. Currently, only a small number of the genes that...