ANRF News And Stories

2011-2012 RA & Lupus Patients Have Dysfunctional “Good” Cholesterol Brian Skaggs, Ph.D.UCLALos Angeles, California Characterization and Effects of Pro-Inflammatory HDL on the Proteome I Human RA and SLE Patients Patients suffering from rheumatoid arthritis and lupus often develop cardiovascular disease at much younger ages than healthy people....

2011-2012 Clarifying Genetic Predisposition to Lupus Jian Zhao, Ph.D.UCLALos Angeles, California The role of Complement Factor H gene polymorphisms in risk for SLE Genetic risk factors are known to be a major contributor for developing lupus. The complement system, a biochemical cascade found in blood circulation...

2011-2012 Collaborative Grant with National Psoriasis Foundation: Year 2 A Study of Psoriatic Arthritis Patients at Increased Risk for Heart Disease Elaine Husni, MD, MPHCleveland Clinic/Case Western Reserve UniversityCleveland, Ohio Recipient of Psoriatic Arthritis Collaborative Grant, co-funded by National Psoriasis Foundation Cardiovascular Biomarkers That May Confer Increased...

2011-2012 Signaling Pathways in Lupus Julie Zikherman, M.D.University of California, San FranciscoSan Francisco, California Investigating how distinct alleles of the phosphatase CD45 differentially regulate B cell tolerance and systemic autoimmunity Systemic lupus erythematosus (lupus) is an autoimmune disease that can result in such devastating outcomes as renal...

2011-2012 Do anti-TNF drugs lessen risk of heart disease? A clinical study Jeffrey Greenberg, MD, MPHNYU School of MedicineNew York, New York FDG PET and MRI Assessments of Atherosclerotic Plaque in RA: Effects on Anti-TNFs and Other Biologic Therapies Cardiovascular (CV) disease is a major medical problem...

2011-2012 The Kelly Award for Juvenile Arthritis Research Altan Ercan, Ph.D.Brigham & Women’s HospitalBoston, Massachusetts Gender-dependent regulation of lgG glycosylation in Juvenile and Adult arthritis At Brigham & Women’s Hospital (Harvard’s teaching hospital), Dr. Ercan is studying the role of the modified antibodies found in both juvenile...

2011-2012 Increasing RA Drug Efficiency: A Clinical Project Massimo Bottini, Ph.D.Sanford-Burnham Medical Research InstituteLa Jolla, California Nanosystem for targeting Treg in vivo Regulatory T cells (Treg) are an immune cell population that plays an active role in protecting humans against rheumatoid arthritis. The delivery of drugs...

2011-2012 Getting at the Root of Knee OA Pain Xin Li, M.D., Ph.DRush University Medical CenterChicago, Illinois Analgesic effect of spinal micro-RNAs on symptomatic knee OA pain Osteoarthritis (OA) affects more than100 million individuals worldwide and causes chronic and severe pain in knee joints. It...

2011-2012 Testing a Novel Way to Treat Arthritis Hye-Jung Kim, PH.D.Dana-Farber Cancer InstituteBoston, Massachusetts CD8+ Treg suppression of collagen-induced arthritis Autoimmune diseases, including Rheumatoid Arthritis (RA), occur when the immune system mistakenly attacks the body’s own tissues. This complex system of cells and antibodies normally destroys “invaders” such as...