ANRF News And Stories

2006-2007 Enzyme Predisposes to Autoimmune Disorders Nunzio Bottini, M.D. University of Southern California Los Angeles, CA PTPN22: Enzymology of an Autoimmune-Predisposing Tyrosine Phosphate Variant Bottini’s laboratory is studying an enzyme called lymphoid phosphatase, which acts as a critical gatekeeper of the activation of immune cells. Individuals carrying a particular...

2007-2008 Focusing on the Cause of OA Noboru Taniguchi, M.D., Ph.D. The Scripps Research Institute La Jolla, CA A novel chromatin protein involved in cartilage homeostasis and osteoarthritis Osteoarthritis is the most prevalent joint disease. It begins with disruption of the cartilage surface and leads to progressive cartilage damage....

2007-2008 New OA Therapy Could Halt Cartilage Destruction Ilse-Gerlinde Sunk, M.D. Harvard School of Dental Medicine Boston, MA Effect of discoidin domain receptor 2 (DDR2) deficiency on osteoarthritis progression in a surgically induced OA mouse model Osteoarthritis (OA), the most common rheumatic disease, is the major cause of disability...

2007-2008 T Cells: Using Your Own Cells to Fight Lupus Brian Skaggs, Ph.D. University of California Los Angeles, CA Understanding the crosstalk between TGFß and Foxp3 in regulatory T cells of systemic lupus erythematosus-prone mice Antibodies produced by immune cells in lupus patients inappropriately bind to many different self-molecules,...

2007-2008 Genetic Factors in Lupus Amr Sawalha, M.D. University of Oklahoma Health Sciences Center Oklahoma City, OK CD40L overexpression in lupus T cells Systemic lupus erythematosus (SLE or lupus) is a chronic, relapsing autoimmune disease that affects multiple organs including the skin, joints, lungs, kidneys and brain. The disease...

2007-2008 Understanding the Defective Immune System Ziaur Rahman, M.D., Ph.D. Thomas Jefferson University Philadelphia, PA Impact of lupus susceptibility loci on peripheral B cell tolerance The human immune system is wonderfully efficient and complex. This system develops weapons, called antibodies, to use against viral and bacterial infections. When antibodies...

2007-2008 From Stem Cells to Cartilage Repair Audrey McAlinden, Ph.D. Washington University School of Medicine St. Louis, MO Induction of articular (hyaline) cartilage differentiation from human adipose-derived mesenchymal stromal cells Articular cartilage is an essential component of our joints, providing a lubricating, low-friction, gliding surface. This tissue contains no...

2007-2008 Growth Factors in Cartilage Cells: A Novel Therapy Chuanju Liu, Ph.D. New York University School of Medicine New York, NY GEP: A Novel Chondrogenic Growth Factor and Target in Arthritis The molecular mechanisms controlling cartilage formation, and specifically those relating to the osteoarthritis, are still unclear. It is...

2007-2008 Understanding Bone Loss in RA Sougata Karmakar, Ph.D. University of Massachusetts Medical School Worcester, MA The role of BMP3 in the pathogenesis of focal articular bone loss in inflammatory arthritis Rheumatoid arthritis (RA) is a chronic, debilitating disease that affects the joints in patients and may result in...

2007-2008 Lupus Therapy Without Toxicity Hee Kap Kang, Ph.D. Northwestern University Chicago, IL Mechanism of Low-dose Tolerance with Nucleosomal Peptide in Lupus Dr. Kang has developed a therapy to repair a cell defect which may cause lupus. To test this therapy, Dr. Kang’s lab is studying the effects of...