ANRF Blog

2003-2004 Modulation of Fibrosis by Statins in Murine Model of Scleroderma Gabriella Lakos, M.D., Ph.D. University of Illinois at Chicago Chicago, IL Scleroderma is a chronic, progressive multi-system connective tissue disorder of unknown etiology with no effective treatment. Five-year mortality approaches 40%, largely due to scarring of...

2003-2004 Role of TLR 3 in Autoimmunity to RNA Binding Proteins Eric Greidinger, M.D. So. Florida VA Foundation, University of Miami Miami, FL Many forms of arthritis are autoimmune diseases because they are associated with immune responses directed against self-proteins. A feature of many of the commonly...

2003-2004 Lifetime Patterns of Body Mass and Quantitative Measure of Osteoarthritis Risk Dana Duren, Ph.D. Wright State University Dayton, OH Adulthood obesity is known to be associated with risk for osteoarthritis (OA). Yet, it is currently unknown what influence childhood or early adulthood weight patterns may have...

2003-2004 Role of NF-kB2/p100 processing in BAFF expression Emmanuel Dejardin, Ph.D. La Jolla Institute for Allergy and Immunology San Diego, CA Dr. Dejardin’s identified molecular pathways that lead to the activation of two subsets of genes. One pathway is implicated in the expression of pro-inflammatory genes. ...

2003-2004 Cav1 (L-type) calcium channels as target for manipulation CD4+ T cell response Abdallah Badou, Ph.D. Yale University School of Medicine-Howard Hughes Medical Institute New Haven, CT Dr. Badou studied how T-cells are activated in RA. These T-cells orchestrate getting the immune system involved in RA. Badou...

2003-2004 Gender Effect on Arthritis Phenotypes in a Murine Model of Rheumatoid Arthritis Vyacheslav Adarichev, Ph.D. Rush-Presbyterian-St. Luke’s Medical Center Chicago, IL Dr. Adarichev is the 2003 recipient of The Sontag Foundation Fellowship of the Arthritis National Research Foundation. This is the third such special fellowship award...

2004-2005 Mechanisms of Action of the Transcription Factor T-bet in Dendritic Cells Jingsong Wang, M.D. Harvard School of Public Health Boston, MA T helper lymphocytes are of two different types, called T helper 1 and T helper 2. They are defined in that manner because they make...

2004-2005 Transcriptional regulation of chondrogenesis via histone modifications Masanao Tsuda, Ph.D. The Scripps Research Institute La Jolla, CA Osteoarthritis (OA) is the disease characterized by progressive joint destruction without regeneration of new cartilage. Regeneration of cartilage relies on appropriate control of chondrocyte development, whose process is tightly regulated...

2004-2005 Effects of BAFF and APRIL Blockade on B cells in Murine Antiphospholipid Syndrome Meera Ramanujam, Ph.D. Columbia University New York, NY Lupus is an autoimmune disease in which B lymphocytes make autoantibodies that deposit in the kidney and may lead to kidney damage. Another major complication...

2004-2005 Plasmacytoid dendritic cell production of IFN-alpha in lupus prone mice Susan Kovats, Ph.D. Beckman Research Institute/City of Hope Duarte, CA Dr. Kovats will be working with former ANRF grant recipient, Chaim Jacob, M.D., Ph.D., of the University of Southern California to study the role of the cytokines,...