ANRF Blog

2007-2008 Understanding Bone Loss in RA Sougata Karmakar, Ph.D. University of Massachusetts Medical School Worcester, MA The role of BMP3 in the pathogenesis of focal articular bone loss in inflammatory arthritis Rheumatoid arthritis (RA) is a chronic, debilitating disease that affects the joints in patients and may result in...

2007-2008 Lupus Therapy Without Toxicity Hee Kap Kang, Ph.D. Northwestern University Chicago, IL Mechanism of Low-dose Tolerance with Nucleosomal Peptide in Lupus Dr. Kang has developed a therapy to repair a cell defect which may cause lupus. To test this therapy, Dr. Kang’s lab is studying the effects of...

2007-2008 Are you susceptible to RA? It may be in your genes… Alyssa Johnsen, M.D., Ph.D. Joslin Diabetes Center Boston, MA Identification of Genes Governing Susceptibility to Inflammatory Arthritis Rheumatoid arthritis (RA) is caused by a complex set of environmental and genetic factors. Currently, only a small number of...

2007-2008 Autoimmune Disorder Target: DRAK2 Martina Gatzka, Ph.D. University of California Irvine, CA Modulation of central and peripheral immunological tolerance by DRAK2, a negative regulatory of lymphocyte signaling This is Dr. Gatzka’s second year of work in autoimmune disorders, studying the body’s natural surveillance mechanisms. When T lymphocytes (T...

2007-2008 A New Model for Treating Scleroderma Edwin Chan, M.D. New York University School of Medicine New York, NY Purinergic Signaling in Dermal Fibrosis Scleroderma is a devastating rheumatic disease affecting many different organs in the body. Unfortunately, there is no effective treatment known at this time. One of...

2007-2008 Beyond TNF: A Newly Discovered Cytokine may provide new target for RA Therapy Christopher Benedict, Ph.D. La Jolla Institute for Allergy and Immunology San Diego, CA Analyzing the contribution of the LIGHT-HVEM-BTLA system in autoimmune arthritis Tumor necrosis factor (TNF) is a cytokine produced by the body’s immune...

2007-2008 Understanding Inflammatory Progression in RA Mei Chen, M.D., Ph.D. Brigham & Women’s Hospital Boston, MA The Mechanisms of LTB4-induced Migration and Invasion in Fibroblast-like Synoviocytes (FLS) Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that primarily targets synovial tissues, which forms the joint lining and produces lubricating...

2008-2009 Osteoarthritis: Targeting a Protein in Cartilage Damage Noboru Taniguchi, M.D., Ph.D. The Scripps Research Institute La Jolla, CA A novel chromatin protein involved in cartilage homeostasis and osteoarthritis Osteoarthritis is the most prevalent joint disease. In 1990 approximately 40 million Americans were affected and this number is predicted...

2008-2009 New RA Therapy Explored: IL-27 Shiva Shahrara, Ph.D. Northwestern University Chicago, IL Recipient of The Sontag Foundation Fellow of the ANRF The Role of IL-27 in Experimental Arthritis IL-17 is a pro-inflammatory mediator that is expressed in rheumatoid arthritis (RA) joint tissue and joint fluid. IL-17 is...

2008-2009 Role of T Cells in Arthritis Christina Roark, Ph.D. National Jewish Medical and Research Center Denver, CO The Regulatory Role of Th-17 Like ?d T Cells in Collagen-Induced Arthritis The importance of the cytokine, IL-17, in autoimmune diseases has led to numerous studies investigating the development of the...