ANRF Blog

2004-2005 Role of AHNAK in calcium signaling in T lymphocytes Koichi Kobayashi, M.D., Ph.D. Yale University School of Medicine New Haven, CT The most recently developed treatments for autoimmune diseases such as rheumatoid arthritis or lupus are based on regulation of an uncontrolled immune system by immunosuppressive drugs....

2004-2005 The role of estrogen receptors in B cell mediated autoreactivity Christine Grimaldi, Ph.D. Columbia University New York, NY Dr. Grimaldi’s study focuses on systemic lupus erythematosus (SLE), an autoimmune disease caused by the production of autoantibodies that mediate tissue damage in target organs, such as the kidney....

2004-2005 Effect of TNF inhibitors on left ventricular structure and function in patients with Rheumatoid Arthritis Jon Giles, M.D. The Johns Hopkins University School of Medicine Baltimore, MD Dr. Giles is the 2004 recipient of the Sontag Foundation Fellowship of the Arthritis National Research Foundation. This is...

2004-2005 Peptidylarginine Deiminase IV: Enzymology of a Rheumatoid Arthritis Susceptibility Gene Product Walter Fast, Ph.D. University of Texas at Austin Austin, TX Rheumatoid arthritis is a chronic inflammatory condition affecting almost 1% of the world’s population. The etiology of this complex disease is still unknown. However,...

2004-2005 Role of Chemokines and matrix metalloproteinases in resolution vs. fibrosis in a murine model of granulomatous experimental autoimmune thryoiditis (G-EAT): implications for pathology and treatment Kemin Chen, M.D., Ph.D. University of Missouri-Columbia School of Medicine Columbia, MD Fibrosis, or scarring, is a relatively common complication in rheumatic...

2004-2005 The roles of TIMP-1 in cartilage degradation and repair after load-induced injury Christopher Chen, Ph.D. The Hospital for Special Surgery New York, NY Osteoarthritis, the leading cause for disability in the U.S., is the object of Dr. Chen’s study. OA is the breakdown of cartilage which...

2004-2005 Potassium Channels in Lymphocytes: Therapeutic Targets for Immunomodulation in Rheumatoid Arthritis Christine Beeton, Ph.D. University of California Irvine, CA Under normal conditions, white blood cells such as T lymphocytes, protect the body against disease-causing mechanisms. In autoimmune diseases such as rheumatoid arthritis (RA), the body attacks...

2005-2006 Beyond TNF: A Newly Discovered Cytokine may provide new target for RA Therapy Christopher Benedict, Ph.D. La Jolla Institute for Allergy and Immunology San Diego, CA Tumor necrosis factor (TNF) is a cytokine produced by the body’s immune cells that fuels the process of inflammation in rheumatoid...

2005-2006 Molecular Pathways to Safer Autoimmune Treatments Koichi Kobayashi, M.D., Ph.D. Harvard University Dana-Farber Cancer Institute Boston, MA Role of AHNAK in calcium signaling in T lymphocytes Current treatments for autoimmune diseases such as rheumatoid arthritis or lupus are based on regulation of an uncontrolled immune system by immunosuppressive...

2005-2006 Increased Estrogen May Alter Immune Response Christine Grimaldi, Ph.D. Columbia University Department of Medicine New York, NY The role of estrogen receptors in B cell autoreactivity Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the production of autoantibodies that may cause tissue damage of...