ANRF News And Stories

2011-2012 Hyaluronan Function in OA Yingcui Li, Ph.D.University of Connecticut Health CenterFarminton, Connecticut Genetic Analysis of Hyaluronan Function in Osteoarthritis Osteoarthritis, the most common type of arthritis, causes pain, disability and decreased quality of life for over 20 million people in the United States alone. Osteoarthritis...

2011-2012 IL-23 May Be Key to New RA Therapy Iannis Adamopoulos, D.Phil.University of California, DavisDavis, California Dissecting the IL-23/IL-17A axis in inflammatory arthritis Dr. Adamopoulos has been named the 2011 Sontag Foundation Fellow of the Arthritis National Research Foundation, an annual award for innovative and cutting-edge rheumatoid...

2011-2012 Targeting Neutrophils in Inflammatory Arthritis Peter Nigrovic, M.D.Children’s Hospital BostonBoston, Massachusetts A novel modulator of neutrophil function in inflammatory arthritis Neutrophils are immune cells that migrate into joints during inflammatory arthritis. Studies in mice confirm that neutrophils are absolutely necessary for the normal evolution of...

2011-2012 Too Much IL-23 may Predispose to Ankylosing Spondylitis Judith Smith, M.D., Ph.DUniversity of WisconsinMadison, Wisconsin Excess IL-23 production and underlying biochemical mechanisms in ankylosing spondylitis Ankylosing spondylitis (AS) is a progressive arthritis involving the spine that causes significant disability and decreased quality of life. Current therapy...

2011-2012 RA & Lupus Patients Have Dysfunctional “Good” Cholesterol Brian Skaggs, Ph.D.UCLALos Angeles, California Characterization and Effects of Pro-Inflammatory HDL on the Proteome I Human RA and SLE Patients Patients suffering from rheumatoid arthritis and lupus often develop cardiovascular disease at much younger ages than healthy people....

2011-2012 Clarifying Genetic Predisposition to Lupus Jian Zhao, Ph.D.UCLALos Angeles, California The role of Complement Factor H gene polymorphisms in risk for SLE Genetic risk factors are known to be a major contributor for developing lupus. The complement system, a biochemical cascade found in blood circulation...

2011-2012 Collaborative Grant with National Psoriasis Foundation: Year 2 A Study of Psoriatic Arthritis Patients at Increased Risk for Heart Disease Elaine Husni, MD, MPHCleveland Clinic/Case Western Reserve UniversityCleveland, Ohio Recipient of Psoriatic Arthritis Collaborative Grant, co-funded by National Psoriasis Foundation Cardiovascular Biomarkers That May Confer Increased...

2011-2012 Signaling Pathways in Lupus Julie Zikherman, M.D.University of California, San FranciscoSan Francisco, California Investigating how distinct alleles of the phosphatase CD45 differentially regulate B cell tolerance and systemic autoimmunity Systemic lupus erythematosus (lupus) is an autoimmune disease that can result in such devastating outcomes as renal...

2011-2012 Do anti-TNF drugs lessen risk of heart disease? A clinical study Jeffrey Greenberg, MD, MPHNYU School of MedicineNew York, New York FDG PET and MRI Assessments of Atherosclerotic Plaque in RA: Effects on Anti-TNFs and Other Biologic Therapies Cardiovascular (CV) disease is a major medical problem...

2011-2012 The Kelly Award for Juvenile Arthritis Research Altan Ercan, Ph.D.Brigham & Women’s HospitalBoston, Massachusetts Gender-dependent regulation of lgG glycosylation in Juvenile and Adult arthritis At Brigham & Women’s Hospital (Harvard’s teaching hospital), Dr. Ercan is studying the role of the modified antibodies found in both juvenile...