ANRF Blog

2008-2009 Specific Cytokine Identified as Risk Factor for Lupus Timothy Niewold, M.D. University of Chicago Chicago, IL Genetic Determinants of Lupus Risk Acting Via the Interferon Alpha Pathway Lupus is a complex disease in which the body's immune system attacks its own tissues and organ systems. For the...

2008-2009 Hormone May Play Role in Controlling Lupus Elaine Lourenco, Ph.D. University of California, Los Angeles Los Angeles, CA The Influence of Leptin on Regulatory T Cells in Murine Lupus The immune system is made of tissues and cells that have the task to protect against disease-causing pathogens or...

2008-2009 Important Osteoarthritis Study Wins Grant for Innovative Science Chuanju Liu, Ph.D. New York University New York, NY Recipient: The Ethelmae Haldan Grant for Innovative Science in Osteoarthritis GEP: A Novel Chondrogenic Growth Factor and Target in Arthritis Arthritis is a degenerative joint disease, occurring primarily in the senior population,...

2008-2009 A Clue to Bone Loss in Rheumatoid Arthritis Sougata Karmakar, Ph.D. University of Massachusetts Worcester, MA The role of BMP3 in the pathogenesis of focal articular bone loss in inflammatory arthritis Rheumatoid arthritis (RA) is a chronic, debilitating disease that affects the joints in patients and may result...

2008-2009 Finding New Genes that Control Inflammatory Arthritis Alyssa Johnsen, M.D., Ph.D. Joslin Diabetes Center Boston, MA Identification of Genes Governing Susceptibility to Inflammatory Arthritis Rheumatoid arthritis (RA) is caused by a complex set of environmental and genetic factors. Currently, only a small number of the genes that...

2008-2009 Pathways of Inflammation in Lupus Lihua Bao, M.D. University of Chicago Chicago, IL Dissect the Roles of C3a and C5a in the Development of Experimental Lupus Nephritis Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease that predominantly affects young women. While SLE can affect just about any...

2008-2009 Mouse Model Mimics Human RA in Late Stages Candace Cham, Ph.D. Stanford University Stanford, CA New Humanized Mouse Model of Chronic Rheumatoid Arthritis in Humans In rheumatoid arthritis (RA), the immune system attacks and damages the individual’s own joints. RA is characterized by episodes of acute inflammation,...

2009-2010 Cytokine Study may lead to New Therapy Yang "Benny" Yi, Ph.D. New York University School of Medicine New York, NY Studies of the roles of IL-23 and IL-22 in arthritogenic Th17 cell responses and the pathogenesis of autoimmune arthritis The immune system mounts protective responses to clear invading...

2009-2010 Molecular Pathways in Lupus Studied Maida Wong, M.D. UCLA Los Angeles, CA James Klinenberg Scholar Programmed death-1-Programmed death-1 ligand (PD-1-PDL-1) pathway in the New Zealand Black x New Zealand white murine model: a molecular approach Dr. Wong’s research will study the molecular pathway of lupus using a mouse model....

2009-2010 Th17 Cell Characteristics may have Implications for all Autoimmune Diseases Sujata Sarkar, M.D. University of Arizona Tucson, AZ Characterization of pathogenic Th17 responses in collagen induced arthritis The question, “Why do we get autoimmune diseases like rheumatoid arthritis?” remains to be answered. All autoimmune disorders is associated...