ANRF Blog

2005-2006 RA Gene Susceptibility Study Walter Fast, Ph.D. The University of Texas at Austin Austin, TX Peptidylarginine Deiminase 4: Enzymology of a Rheumatoid Arthritis Susceptibility Gene Product Rheumatoid arthritis is a chronic inflammatory condition affecting almost 1% of the world’s population. The cause of this complex disease is still...

2005-2006 Reversing Fibrosis Kemin Chen, M.D., Ph.D. University of Missouri-Columbia Columbia, MO Role of Chemokines and matrix metalloproteinases in resolution vs fibrosis in a murine model of granulomatous experimental autoimmune thyroiditis (G-EAT): implications for pathology and treatment Fibrosis is the cycle of damage-healing-scarring-damage, etc. in inflammatory disease. The functions...

2005-2006 Alternative to Immunosuppressive Drugs Song Guo Zheng, M.D. University of Southern California Los Angeles, CA Effects of TGF-B on both CD4+ and CD8+ cells are required for optimal generation and function of regulatory cells Certain cells that respond to self tissues or organs exist in normal humans; however,...

2005-2006 Novel Imaging Technique Xueding Wang, Ph.D. University of Michigan Ann Arbor, MI Photoacoustic tomography of inflammatory arthritis The 2005-2006 Sontag Foundation Fellowship award recipient, Xueding Wang, Ph.D., developed a new technique using laser technology to provide images of soft tissues such as joints affected by arthritis. He will...

2005-2006 Preventing Bone Loss in RA Nicole Cherie Walsh, Ph.D. Beth Israel Deaconess Medical Center, Harvard Institute of Medicine Boston, MA The role of T cells in the pathogenesis of focal articular bone loss in inflammatory arthritis The structural integrity of bone is maintained by the coordinated actions of...

2005-2006 Cartilage Regeneration in OA Anna Spagnoli, M.D. Vanderbilt University Medical Center Memphis, TN Role of insulin-like growth factor (IGF-I) in mesenchymal stem cell cartilage regeneration In industrialized countries, osteoarthritis affects over one-third of the adult population. Since cartilage is unable to repair itself, treatments for osteoarthritis primarily cover...

2005-2006 Understanding the Immune System Adam Mor, M.D. New York University School of Medicine, Hospital for Joint Diseases New York, NY Ras signaling in Autoimmune T cells: Spatiotemporal Ras signaling in primary T cells The immune system is designed to protect us from infection, but when its regulation is...

2005-2006 The Role of B Cells in RA Taras Lyubchenko, Ph.D. University of Colorado Health Sciences Center Denver, CO Role of complement receptor 2 (CR2/CD21) in B cell receptor signal transduction Understanding the mechanisms underlying activation of antibody-producing B cells is particularly important in autoimmune diseases such as...

2005-2006 Gene Therapy for Lupus Martin Kriegel, M.D. Yale University School of Medicine New Haven, CT T Cell-specific Deletion of GRAIL – the gene related to anergy in lymphocytes One key mechanism to preserve normal immune response – called T cell anergy – is disturbed in SLE patients and...

2005-2006 Proteins that may cause RA Myung-Shin Jeon, Ph.D. La Jolla Institute for Allergy and Immunology San Diego, CA c-Cbl in the development of autoimmune arthritis T cells are the critical components in the initiation and the maintenance of autoimmune diseases, such as rheumatoid arthritis. Dr. Myung-Shin Jeon will...