12 Sep 2012
2009-2010 Molecular Pathways in Lupus Studied Maida Wong, M.D. UCLA Los Angeles, CA James Klinenberg Scholar Programmed death-1-Programmed death-1 ligand (PD-1-PDL-1) pathway in the New Zealand Black x New Zealand white murine model: a molecular approach Dr. Wong’s research will study the molecular pathway of lupus using a mouse model....
12 Sep 2012
2009-2010 Th17 Cell Characteristics may have Implications for all Autoimmune Diseases Sujata Sarkar, M.D. University of Arizona Tucson, AZ Characterization of pathogenic Th17 responses in collagen induced arthritis The question, “Why do we get autoimmune diseases like rheumatoid arthritis?” remains to be answered. All autoimmune disorders is associated...
12 Sep 2012
2009-2010 The Role of Neutrophils in Inflammatory Arthritis Peter Nigrovic, M.D. Children’s Hospital Boston Boston, MA John Vaughan Scholar A novel modulator of neutrophil function in inflammatory arthritis Neutrophils are immune cells that migrate into the joint cavity during inflammatory arthritis. Studies in mice confirm that neutrophils are absolutely...
12 Sep 2012
2009-2010 Specific Cytokine Identified as Risk Factor for Lupus Timothy Niewold, M.D. University of Chicago Chicago, IL Eng Tan Scholar Genetic Regulation of Interferon Alpha Human Lupus Lupus is a complex disease in which the body's immune system attacks its own tissues and organ systems. For the most part,...
12 Sep 2012
2009-2010 Targeting Osteoarthritis Shigeru Miyaki, Ph.D. The Scripps Research Institute La Jolla, CA The role of cartilage-specific microRNA in osteoarthritis pathogenesis Osteoarthritis (OA), the most prevalent, age-related joint disease, is characterized by degradation in joint cartilage. Molecular mechanisms that govern the development and maintenance of cartilage are being...
12 Sep 2012
2009-2010 Hormone May Play Role in Controlling Lupus Elaine Lourenco, Ph.D. UCLA Los Angeles, CA Josephine Rich Memorial Fellow The Influence of Leptin on Regulatory T cells in Murine Lupus The immune system is made of tissues and cells that have the task to protect against disease-causing pathogens or tumors....
12 Sep 2012
2009-2010 Making a New Meniscus Mai Thuy Lam, Ph.D. Stanford University Stanford, CA Ethelmae Haldan Grant for Innovative Research in Osteoarthritis Multi-factor knee meniscus tissue engineering Osteoarthritis (OA) is the most common type of arthritis, and is often viewed as age-related, “wear and tear” degeneration of the cartilage lining the...
12 Sep 2012
2009-2010 Finding the Genes that Cause Lupus Courtney Gray-McGuire, Ph.D. Oklahoma Medical Research Foundation Oklahoma City, OK Genes for early systemic lupus erythematosus autoimmunity in African Americans Systemic lupus erythematosus (SLE or lupus) is a complex disease with a variety of clinical manifestations, many of which can be debilitating...
12 Sep 2012
2009-2010 T Cells: A Novel Treatment for Rheumatoid Arthritis Richard Di Paolo, Ph.D. St. Louis University St. Louis, MO Don H. Minassian Memorial Fellow Adoptively Transferring GPI-specific Regulatory T cells to treat the Effector Phase of Rheumatoid Arthritis The immune system generates a population of cells known as regulatory T...
12 Sep 2012
2009-2010 Understanding Inflammatory Progression in RA Mei Chen, M.D., Ph.D. Brigham and Women’s Hospital Boston, MA Frances D. Morongo Memorial Fellow The mechanisms of LTB4-induced migration and invasion in fibroblast-like synoviocytes (FLS) Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that primarily targets synovial tissues, which forms the joint...
