12 Sep 2012
2005-2006 Using a New Genetic Tool Hongbo Chi, Ph.D. Yale University School of Medicine New Haven, CT S1P1 and regulation of autoimmune disease T lymphocytes, a type of white blood cell, play a central role in the regulation of immune responses against infection. The function of T lymphocytes is...
12 Sep 2012
2005-2006 New Therapeutic Target for Lupus David Cauvi, Ph.D. The Scripps Research Institute La Jolla, CA Decay accelerating factor and systemic autoimmunity Systemic lupus erythematosus (SLE or lupus) is a devastating chronic autoimmune disease affecting multiple organ systems and characterized by a broad array of antibodies. Dr. David Cauvi’s...
12 Sep 2012
2006-2007 Alternative to Immunosuppressive Drugs Song Guo Zheng, M.D. University of Southern California Los Angeles, CA Effects of TGF-beta on both CD4+ and CD8+ cells are required for optimal generation and function of regulatory T cells Certain cells that respond to self tissues or organs exist in normal humans;...
12 Sep 2012
2006-2007 Preventing Bone Loss in RA Nicole Cherie Walsh, Ph.D. Beth Israel Deaconess Medical Center, Harvard Institute of Medicine Boston, MA The role of T cells in the pathogenesis of focal articular bone loss in inflammatory arthritis The structural integrity of bone is maintained by the coordinated actions of...
12 Sep 2012
2006-2007 Cartilage Regeneration in OA Anna Spagnoli, M.D. Vanderbilt University Medical Center Memphis, TN Role of Insulin-like Growth Factor-I (IGF-I) in Mesenchymal Stem Cell Cartilage Regeneration In industrialized countries, osteoarthritis affects over one-third of the adult population. Since cartilage is unable to repair itself, treatments for osteoarthritis primarily cover...
12 Sep 2012
2006-2007 Understanding the Immune System Adam Mor, M.D. New York University School of Medicine, Hospital for Joint Diseases New York, NY Ras signaling in autoimmune T cells: Mechanism of Ras activation on the Golgi apparatus The immune system is designed to protect us from infection, but when its regulation...
12 Sep 2012
2006-2007 The Role of B Cells in RA Taras Lyubchenko, Ph.D. University of Colorado Health Sciences Center Denver, CO Role of Complement Receptor 2 (CR2/CD21) in B cell receptor signal transduction Understanding the mechanisms underlying activation of antibody-producing B cells is particularly important in autoimmune diseases such as rheumatoid...
12 Sep 2012
2006-2007 Using a New Genetic Tool Hongbo Chi, Ph.D. Yale University School of Medicine New Haven, CT S1P Receptors and Regulation of Immunity and Autoimmune Disease T lymphocytes, a type of white blood cell, play a central role in the regulation of immune responses against infection. The function of...
12 Sep 2012
2006-2007 Cartilage Regeneration Study Li Zeng, Ph.D. Tufts University School of Medicine Boston, MA Nkx3.2 nuclear localization and cartilage formation Arthritis is a widespread, debilitating disease in which the joint cartilage slowly disintegrates. One of the possible remedies for this disease is to regenerate cartilage and transplant the regenerated...
12 Sep 2012
2006-2007 Autoimmune Disease Inhibited by T Regulatory Cells Shiguang Yu, Ph.D. University of Missouri Columbia, MO Mechanisms by which CD4 and CD25 Regulatory T Cells inhibit Autoimmune Diseases in the Absence of B Cells Autoimmune diseases arise when the immune system reacts against self tissues or organs. Low activity...
