ANRF Blog

2009-2010 The Role of Neutrophils in Inflammatory Arthritis Peter Nigrovic, M.D. Children’s Hospital Boston Boston, MA John Vaughan Scholar A novel modulator of neutrophil function in inflammatory arthritis Neutrophils are immune cells that migrate into the joint cavity during inflammatory arthritis. Studies in mice confirm that neutrophils are absolutely...

2009-2010 Specific Cytokine Identified as Risk Factor for Lupus Timothy Niewold, M.D. University of Chicago Chicago, IL Eng Tan Scholar Genetic Regulation of Interferon Alpha Human Lupus Lupus is a complex disease in which the body's immune system attacks its own tissues and organ systems. For the most part,...

2009-2010 Targeting Osteoarthritis Shigeru Miyaki, Ph.D. The Scripps Research Institute La Jolla, CA The role of cartilage-specific microRNA in osteoarthritis pathogenesis Osteoarthritis (OA), the most prevalent, age-related joint disease, is characterized by degradation in joint cartilage. Molecular mechanisms that govern the development and maintenance of cartilage are being...

2009-2010 Hormone May Play Role in Controlling Lupus Elaine Lourenco, Ph.D. UCLA Los Angeles, CA Josephine Rich Memorial Fellow The Influence of Leptin on Regulatory T cells in Murine Lupus The immune system is made of tissues and cells that have the task to protect against disease-causing pathogens or tumors....

2009-2010 Making a New Meniscus Mai Thuy Lam, Ph.D. Stanford University Stanford, CA Ethelmae Haldan Grant for Innovative Research in Osteoarthritis Multi-factor knee meniscus tissue engineering Osteoarthritis (OA) is the most common type of arthritis, and is often viewed as age-related, “wear and tear” degeneration of the cartilage lining the...

2009-2010 Finding the Genes that Cause Lupus Courtney Gray-McGuire, Ph.D. Oklahoma Medical Research Foundation Oklahoma City, OK Genes for early systemic lupus erythematosus autoimmunity in African Americans Systemic lupus erythematosus (SLE or lupus) is a complex disease with a variety of clinical manifestations, many of which can be debilitating...

2009-2010 T Cells: A Novel Treatment for Rheumatoid Arthritis Richard Di Paolo, Ph.D. St. Louis University St. Louis, MO Don H. Minassian Memorial Fellow Adoptively Transferring GPI-specific Regulatory T cells to treat the Effector Phase of Rheumatoid Arthritis The immune system generates a population of cells known as regulatory T...

2009-2010 Understanding Inflammatory Progression in RA Mei Chen, M.D., Ph.D. Brigham and Women’s Hospital Boston, MA Frances D. Morongo Memorial Fellow The mechanisms of LTB4-induced migration and invasion in fibroblast-like synoviocytes (FLS) Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that primarily targets synovial tissues, which forms the joint...

2009-2010 Testing a New Therapy Candace Cham, Ph.D. Stanford University Stanford, CA Jack and Vonnie Schlomer Memorial Fellow New humanized mouse model of chronic rheumatoid arthritis in humans In rheumatoid arthritis (RA), the immune system attacks and damages the individual’s own joints. RA is characterized by episodes of acute...

2011-2012 Hyaluronan Function in OA Yingcui Li, Ph.D.University of Connecticut Health CenterFarminton, Connecticut Genetic Analysis of Hyaluronan Function in Osteoarthritis Osteoarthritis, the most common type of arthritis, causes pain, disability and decreased quality of life for over 20 million people in the United States alone. Osteoarthritis...