ANRF Blog

2009-2010 Hormone May Play Role in Controlling Lupus Elaine Lourenco, Ph.D. UCLA Los Angeles, CA Josephine Rich Memorial Fellow The Influence of Leptin on Regulatory T cells in Murine Lupus The immune system is made of tissues and cells that have the task to protect against disease-causing pathogens or tumors....

2009-2010 Making a New Meniscus Mai Thuy Lam, Ph.D. Stanford University Stanford, CA Ethelmae Haldan Grant for Innovative Research in Osteoarthritis Multi-factor knee meniscus tissue engineering Osteoarthritis (OA) is the most common type of arthritis, and is often viewed as age-related, “wear and tear” degeneration of the cartilage lining the...

2009-2010 Finding the Genes that Cause Lupus Courtney Gray-McGuire, Ph.D. Oklahoma Medical Research Foundation Oklahoma City, OK Genes for early systemic lupus erythematosus autoimmunity in African Americans Systemic lupus erythematosus (SLE or lupus) is a complex disease with a variety of clinical manifestations, many of which can be debilitating...

2009-2010 T Cells: A Novel Treatment for Rheumatoid Arthritis Richard Di Paolo, Ph.D. St. Louis University St. Louis, MO Don H. Minassian Memorial Fellow Adoptively Transferring GPI-specific Regulatory T cells to treat the Effector Phase of Rheumatoid Arthritis The immune system generates a population of cells known as regulatory T...

2009-2010 Understanding Inflammatory Progression in RA Mei Chen, M.D., Ph.D. Brigham and Women’s Hospital Boston, MA Frances D. Morongo Memorial Fellow The mechanisms of LTB4-induced migration and invasion in fibroblast-like synoviocytes (FLS) Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that primarily targets synovial tissues, which forms the joint...

2009-2010 Testing a New Therapy Candace Cham, Ph.D. Stanford University Stanford, CA Jack and Vonnie Schlomer Memorial Fellow New humanized mouse model of chronic rheumatoid arthritis in humans In rheumatoid arthritis (RA), the immune system attacks and damages the individual’s own joints. RA is characterized by episodes of acute...

2011-2012 Hyaluronan Function in OA Yingcui Li, Ph.D.University of Connecticut Health CenterFarminton, Connecticut Genetic Analysis of Hyaluronan Function in Osteoarthritis Osteoarthritis, the most common type of arthritis, causes pain, disability and decreased quality of life for over 20 million people in the United States alone. Osteoarthritis...

2011-2012 IL-23 May Be Key to New RA Therapy Iannis Adamopoulos, D.Phil.University of California, DavisDavis, California Dissecting the IL-23/IL-17A axis in inflammatory arthritis Dr. Adamopoulos has been named the 2011 Sontag Foundation Fellow of the Arthritis National Research Foundation, an annual award for innovative and cutting-edge rheumatoid...

2011-2012 Targeting Neutrophils in Inflammatory Arthritis Peter Nigrovic, M.D.Children’s Hospital BostonBoston, Massachusetts A novel modulator of neutrophil function in inflammatory arthritis Neutrophils are immune cells that migrate into joints during inflammatory arthritis. Studies in mice confirm that neutrophils are absolutely necessary for the normal evolution of...

2011-2012 Too Much IL-23 may Predispose to Ankylosing Spondylitis Judith Smith, M.D., Ph.DUniversity of WisconsinMadison, Wisconsin Excess IL-23 production and underlying biochemical mechanisms in ankylosing spondylitis Ankylosing spondylitis (AS) is a progressive arthritis involving the spine that causes significant disability and decreased quality of life. Current therapy...