ANRF Blog

2007-2008 T Cells: Using Your Own Cells to Fight Lupus Brian Skaggs, Ph.D. University of California Los Angeles, CA Understanding the crosstalk between TGFß and Foxp3 in regulatory T cells of systemic lupus erythematosus-prone mice Antibodies produced by immune cells in lupus patients inappropriately bind to many different self-molecules,...

2007-2008 Genetic Factors in Lupus Amr Sawalha, M.D. University of Oklahoma Health Sciences Center Oklahoma City, OK CD40L overexpression in lupus T cells Systemic lupus erythematosus (SLE or lupus) is a chronic, relapsing autoimmune disease that affects multiple organs including the skin, joints, lungs, kidneys and brain. The disease...

2007-2008 Understanding the Defective Immune System Ziaur Rahman, M.D., Ph.D. Thomas Jefferson University Philadelphia, PA Impact of lupus susceptibility loci on peripheral B cell tolerance The human immune system is wonderfully efficient and complex. This system develops weapons, called antibodies, to use against viral and bacterial infections. When antibodies...

2007-2008 From Stem Cells to Cartilage Repair Audrey McAlinden, Ph.D. Washington University School of Medicine St. Louis, MO Induction of articular (hyaline) cartilage differentiation from human adipose-derived mesenchymal stromal cells Articular cartilage is an essential component of our joints, providing a lubricating, low-friction, gliding surface. This tissue contains no...

2007-2008 Growth Factors in Cartilage Cells: A Novel Therapy Chuanju Liu, Ph.D. New York University School of Medicine New York, NY GEP: A Novel Chondrogenic Growth Factor and Target in Arthritis The molecular mechanisms controlling cartilage formation, and specifically those relating to the osteoarthritis, are still unclear. It is...

2007-2008 Understanding Bone Loss in RA Sougata Karmakar, Ph.D. University of Massachusetts Medical School Worcester, MA The role of BMP3 in the pathogenesis of focal articular bone loss in inflammatory arthritis Rheumatoid arthritis (RA) is a chronic, debilitating disease that affects the joints in patients and may result in...

2007-2008 Lupus Therapy Without Toxicity Hee Kap Kang, Ph.D. Northwestern University Chicago, IL Mechanism of Low-dose Tolerance with Nucleosomal Peptide in Lupus Dr. Kang has developed a therapy to repair a cell defect which may cause lupus. To test this therapy, Dr. Kang’s lab is studying the effects of...

2007-2008 Are you susceptible to RA? It may be in your genes… Alyssa Johnsen, M.D., Ph.D. Joslin Diabetes Center Boston, MA Identification of Genes Governing Susceptibility to Inflammatory Arthritis Rheumatoid arthritis (RA) is caused by a complex set of environmental and genetic factors. Currently, only a small number of...

2007-2008 Autoimmune Disorder Target: DRAK2 Martina Gatzka, Ph.D. University of California Irvine, CA Modulation of central and peripheral immunological tolerance by DRAK2, a negative regulatory of lymphocyte signaling This is Dr. Gatzka’s second year of work in autoimmune disorders, studying the body’s natural surveillance mechanisms. When T lymphocytes (T...

2007-2008 A New Model for Treating Scleroderma Edwin Chan, M.D. New York University School of Medicine New York, NY Purinergic Signaling in Dermal Fibrosis Scleroderma is a devastating rheumatic disease affecting many different organs in the body. Unfortunately, there is no effective treatment known at this time. One of...