12 Sep 2012
2006-2007 Understanding OA Hee-Jeong Im Sampen, Ph.D. Rush University Medical Center Chicago, IL IL-1beta altered SUMO pathway in the Pathogenesis of Osteoarthritis Osteoarthritis is a disease that causes significant pain and disability. Given the increasing prevalence of OA in the aging population around the world, its public health impact...
12 Sep 2012
2006-2007 Insuring B Cell Tolerance Julie Lang, Ph.D. University of Colorado Health Sciences Center Denver, CO The role of CR2 in central and peripheral tolerance A subset of white blood cells, known as B lymphocytes, is responsible for generating antibodies during an immune response to infection. In normal individuals,...
12 Sep 2012
2006-2007 A Lupus Therapy without Toxicity Hee Kap Kang, Ph.D. Northwestern University Chicago, IL Mechanism of Low-dose Tolerance with Nucleosomal Peptides in Lupus Dr. Kang has developed a therapy to repair a cell defect which may cause lupus. To test this therapy, Dr. Kang’s lab is studying the effects...
12 Sep 2012
2006-2007 Defining Genetics of RA in African Americans Damini Jawaheer, Ph.D. UCLA Semel Institute for Neuroscience and Human Behavior Los Angeles, CA Variations in Candidate Gene Polymorphisms Associated with RA in African Americans This is a genetic study of African Americans with RA. Dr. Jawaheer will test and map...
12 Sep 2012
2006-2007 DRAK2: Target for New Therapy Martina Gatzka, M.D. University of California Irvine, CA Modulation of central and peripheral immunological tolerance by DRAK2, a negative regulator of lymphocyte signaling When T lymphocytes, a type of white blood cell, cannot distinguish between self and non-self tissues, they contribute to inflammation...
12 Sep 2012
2006-2007 Arthritis and Growth in Children Hulya Bukulmez, M.D. Case Western Reserve University Cleveland, OH Does disruption of the C-type natriuretic peptide (CNP) signaling pathway cause cartilage degradation and growth retardation in juvenile rheumatoid arthritis? Dr. Bukulmez is studying the effect of chronic arthritis on a child’s growth. The...
12 Sep 2012
2006-2007 Enzyme Predisposes to Autoimmune Disorders Nunzio Bottini, M.D. University of Southern California Los Angeles, CA PTPN22: Enzymology of an Autoimmune-Predisposing Tyrosine Phosphate Variant Bottini’s laboratory is studying an enzyme called lymphoid phosphatase, which acts as a critical gatekeeper of the activation of immune cells. Individuals carrying a particular...
12 Sep 2012
2007-2008 Focusing on the Cause of OA Noboru Taniguchi, M.D., Ph.D. The Scripps Research Institute La Jolla, CA A novel chromatin protein involved in cartilage homeostasis and osteoarthritis Osteoarthritis is the most prevalent joint disease. It begins with disruption of the cartilage surface and leads to progressive cartilage damage....
12 Sep 2012
2007-2008 New OA Therapy Could Halt Cartilage Destruction Ilse-Gerlinde Sunk, M.D. Harvard School of Dental Medicine Boston, MA Effect of discoidin domain receptor 2 (DDR2) deficiency on osteoarthritis progression in a surgically induced OA mouse model Osteoarthritis (OA), the most common rheumatic disease, is the major cause of disability...
12 Sep 2012
2007-2008 T Cells: Using Your Own Cells to Fight Lupus Brian Skaggs, Ph.D. University of California Los Angeles, CA Understanding the crosstalk between TGFß and Foxp3 in regulatory T cells of systemic lupus erythematosus-prone mice Antibodies produced by immune cells in lupus patients inappropriately bind to many different self-molecules,...
