ANRF Blog

2007-2008 Autoimmune Disorder Target: DRAK2 Martina Gatzka, Ph.D. University of California Irvine, CA Modulation of central and peripheral immunological tolerance by DRAK2, a negative regulatory of lymphocyte signaling This is Dr. Gatzka’s second year of work in autoimmune disorders, studying the body’s natural surveillance mechanisms. When T lymphocytes (T...

2007-2008 A New Model for Treating Scleroderma Edwin Chan, M.D. New York University School of Medicine New York, NY Purinergic Signaling in Dermal Fibrosis Scleroderma is a devastating rheumatic disease affecting many different organs in the body. Unfortunately, there is no effective treatment known at this time. One of...

2007-2008 Beyond TNF: A Newly Discovered Cytokine may provide new target for RA Therapy Christopher Benedict, Ph.D. La Jolla Institute for Allergy and Immunology San Diego, CA Analyzing the contribution of the LIGHT-HVEM-BTLA system in autoimmune arthritis Tumor necrosis factor (TNF) is a cytokine produced by the body’s immune...

2007-2008 Understanding Inflammatory Progression in RA Mei Chen, M.D., Ph.D. Brigham & Women’s Hospital Boston, MA The Mechanisms of LTB4-induced Migration and Invasion in Fibroblast-like Synoviocytes (FLS) Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that primarily targets synovial tissues, which forms the joint lining and produces lubricating...

2008-2009 Osteoarthritis: Targeting a Protein in Cartilage Damage Noboru Taniguchi, M.D., Ph.D. The Scripps Research Institute La Jolla, CA A novel chromatin protein involved in cartilage homeostasis and osteoarthritis Osteoarthritis is the most prevalent joint disease. In 1990 approximately 40 million Americans were affected and this number is predicted...

2008-2009 New RA Therapy Explored: IL-27 Shiva Shahrara, Ph.D. Northwestern University Chicago, IL Recipient of The Sontag Foundation Fellow of the ANRF The Role of IL-27 in Experimental Arthritis IL-17 is a pro-inflammatory mediator that is expressed in rheumatoid arthritis (RA) joint tissue and joint fluid. IL-17 is...

2008-2009 Role of T Cells in Arthritis Christina Roark, Ph.D. National Jewish Medical and Research Center Denver, CO The Regulatory Role of Th-17 Like ?d T Cells in Collagen-Induced Arthritis The importance of the cytokine, IL-17, in autoimmune diseases has led to numerous studies investigating the development of the...

2008-2009 Genetic Study of Defective Tolerance in Lupus Ziaur Rahman, M.D., Ph.D. Thomas Jefferson University Philadelphia, PA Impact of lupus susceptibility loci on peripheral B cell tolerance Virginia L. Riddle Memorial Fellowship of the ANRF The body has an efficient and complex system known as the immune system that develops...

2008-2009 Specific Cytokine Identified as Risk Factor for Lupus Timothy Niewold, M.D. University of Chicago Chicago, IL Genetic Determinants of Lupus Risk Acting Via the Interferon Alpha Pathway Lupus is a complex disease in which the body's immune system attacks its own tissues and organ systems. For the...

2008-2009 Hormone May Play Role in Controlling Lupus Elaine Lourenco, Ph.D. University of California, Los Angeles Los Angeles, CA The Influence of Leptin on Regulatory T Cells in Murine Lupus The immune system is made of tissues and cells that have the task to protect against disease-causing pathogens or...

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