Previous Grant Recipients

2001-2002 Wolfgang Hueber, M.D. Stanford University School of Medicine Stanford, CA Dr. Hueber will study a novel animal model of systemic lupus erythematosus (SLE or lupus), utilizing powerful new technology called protein microarray technique, to identify and characterize the immune response. This research holds great promise for...

2001-2002 Xin Dong, Ph.D. University of Pittsburgh School of Medicine Pittsburgh, PA More than 80 percent of rheumatoid arthritis patients produce antibodies against their own immune system, called rheumatoid factors. It is believed that rheumatoid factor production by B cells is controlled by specific "antibody-reactive" T cells....

2001-2002 Recipient of the Sontag Foundation Fellowship of the Arthritis National Research Foundation Mireille Delhase, Ph.D. University of California San Diego, CA Rheumatoid Arthritis (RA) is a common chronic inflammatory disease, characterized by joint inflammation and progressive cartilage destruction. Molecules, called cytokines, produced by cells from the immune...

2001-2002 Karen Costenbader, M.D. Brigham and Women's Hospital Boston, MA Dr. Costenbader is conducting a randomized, double-blind study of 50 lupus patients to determine the appropriate dosing level of Pravastatin, an oral medication proven to reduce cholesterol levels in the general population. No studies have been done...

2002-2003 In vivo real time imaging of proteinase activity in arthritis mouse models Koichiro Ohmura, M.D., Ph.D. Joslin Diabetes Center (affiliated with Harvard Medical School) Boston, MA Dr. Ohmura is perfecting an imaging technology with the potential to greatly benefit the diagnosis of, research on and monitoring the...

2002-2003 Immunomodulatory CD28 Peptides in the treatment of Collagen-Induced Arthritis Mythily Srinivasan, M.D.S., Ph.D. Ohio State University Columbus, OH The goals of Dr. Srinivasan’s study are to explore the therapeutic advantages of preventing and improving arthritis through treatment with a synthetic peptide. They will use a mouse model...

2002-2003 Interleukin-4 Potentiates Peripheral Deletion of Autoreactive Th1 Cells in Proteoglycan-Induced Arthritis Jian Zhang, M.D. Rush-Presbyterian – St. Luke’s Medical Center Chicago, IL Dr. Zhang is studying the mechanism of treating RA with a cytokine called Interleukin-4, which is thought to retard the disease development by inducing apoptosis...

2002-2003 The role of DRAK2, a lymphoid-enriched apoptotic nuclear DAP-like kinase, in T cell activation and autoimmunity Craig Walsh, Ph.D. University of California Irvine, CA Dr. Walsh’s study is aimed at understanding the basic mechanisms that prevent inappropriate lymphocyte activation in autoimmune diseases, such as rheumatoid arthritis. He...

2002-2003 Inducer-specific TNF-alpha gene regulation in T lymphocytesAlla Tsytsykova, Ph.D. The Center for Blood Research (affiliated with Harvard University) Boston, MA This is the second year Dr. Tsytsykova has received funding for her work from ANRF. She is continuing her work studying the process by which the...

2002-2003 Role of protein kinase R in TNF-alpha production Kristine Phillips, M.D., Ph.D. Brigham and Women’s Hospital (affiliated with Harvard Medical School) Boston, MA Dr. Phillips’ study is evaluating how different levels of TNR-alpha protein are produced. Treatment of arthritis has been revolutionized by the use of biologic...