Previous Grant Recipients

2002-2003 The Role of p21 in regulating IL-6 and MMP in RA Harris Perlman, Ph.D. Saint Louis University St Louis, MO Dr. Perlman has identified a gene, p21 that prevents growth and secretion of pro-inflammatory molecules in rheumatoid arthritis. He is studying the pathways of this gene, trying...

2002-2003 Prevention and treatment of Collagen-Induced Arthritis by adoptive cellular gene therapy Alenka Levicnik, M.D. Stanford University School of Medicine Stanford, CT Dr. Levicknik is studying a mouse model of rheumatoid arthritis (RA) similar to human RA. She is attempting a new treatment regimen, adoptive cellular gene therapy....

2002-2003 Characterization of Autoantibody-Reactive T Lymphocytes in Murine Systemic Lupus Erythematosus (SLE) Antonio La Cava, M.D., Ph.D. UCLA Los Angeles, CA Dr. La Cava will study the characteristics of the cells responsible for the regulation of immune responses in a mouse model that spontaneously develops lupus. The results...

2002-2003 Identification of T cell epitopes that are relevant in the pathogenesis and progression of pediatric SLE. Francesca Giannoni, Ph.D. University of California-San Diego San Diego, CA Dr. Giannoni’s project consists of the identification and characterization of the self-proteins thought to cause inflammation in children with lupus. They...

2002-2003 Role of NFFAT Proteins in DC154 Gene Regulation and Lupus Randy Cron, M.D., Ph.D. The Children’s Hospital of Philadelphia – University of Pennsylvania Philadelphia, PA Recent findings show that a protein, CD154, is abnormally expressed on the surface of certain white cells of lupus patients. While a...

2002-2003 Elucidating the Mechanism of Receptor Editing Cynthia Benedict, Ph.D. Princeton University Princeton, NJ How the Ig Heavy or Light Chain may be Rearranged Secondarily to Avoid Autoreactivity. Dr. Benedict’s study centers on the effects of anti-DNA antibodies in systemic lupus erythematosus (SLE or lupus). She will examine genetically...

2002-2003 Autoantibodies to GPI in Rheumatoid Arthritis Pathogenesis. Monica Schaller, Ph.D. The Scripps Research Institute La Jolla, CA Dr. Schaller is studying an enzyme present in all cells of the human body, GPI (glucose-6-phosphate isomerase). Preliminary studies indicate that anti-GPI antibodies, found in higher levels in the blood...

2003-2004 Generation of antigen-specific T regulatory cells in TCR transgenic mice to prevent the collagen-induced arthritis Song Guo Zheng, M.D. University of Southern CaliforniaLos Angeles, CA The objective of Dr. Zheng’s project was to develop therapy for RA that is effective, but without significant toxicity. RA...

2003-2004 Fine mapping of the significantly linked SLE susceptibility loci at 1q23-24 in multiethnic groups Hui Wu, M.D. UCLA School of Medicine Los Angeles, CA Systemic Lupus Erythematosus (SLE or lupus) occurs more frequently in families of SLE than in the general population. Dr. Wu observed strong...

2003-2004 Autoantibodies to GPI in human inflammatory arthritides Monica M. Schaller, Ph.D. The Scripps Research Institute La Jolla, CA Dr. Schaller enjoys the distinction of receiving an ANRF grant award in two consecutive years. This is a continuation of her study from the previous year, seeking to...