Can folds in your DNA cause Psoriatic Arthritis?

Can folds in your DNA cause Psoriatic Arthritis?

Can DNA be the cause of autoimmune forms of arthritis? Current Arthritis National Research Foundation grantee Dr. Iouri Chepelev is specifically looking at how DNA folds might lead to psoriatic arthritis.

In this episode of Arthritis Now, we talk with Iouri Chepelev, PhD, who is the 2015-2016 ANRF and National Psoriasis Foundation grant recipient, of the Cincinnati Children’s Medical Center. We learn about his research into genetics, and specifically his work on psoriatic arthritis.

Out of 3 billion letters in the human DNA, he is currently focusing his research on 1/1000th of the human genome to look for clues as to why psoriatic arthritis occurs. One such clue he is looking at is how our DNA folds to fit inside of our cells. Each cell contains DNA that is 2 meters long, and Dr. Chepelev’s research on psoriatic arthritis suggests that if it folds incorrectly, this could actually be the underlying cause of psoriatic arthritis and many autoimmune diseases. This research will lead to a better understanding of why psoriatic arthritis and related autoimmune diseases occur, and improved treatment options.

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Arthritis National Research Foundation

The Arthritis National Research Foundation's mission is to provide initial research funding to brilliant, investigative scientists with new ideas to cure arthritis and related autoimmune diseases. There are several ways to support research through the ANRF. Find out more and donate today.

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