Hongbo Chi, Ph.D.

Hongbo Chi, Ph.D.


Using a New Genetic Tool

Hongbo Chi, Ph.D.

Yale University School of Medicine
New Haven, CT
S1P1 and regulation of autoimmune disease

T lymphocytes, a type of white blood cell, play a central role in the regulation of immune responses against infection. The function of T lymphocytes is critically dependent upon their ability to distinguish between self and non-self. The inappropriate recognition of self tissues by T lymphocytes leads to many autoimmune diseases; the most representative systemic autoimmune disease in humans is systemic lupus erythematosus (SLE or lupus). Therapeutic intervention of SLE and other rheumatic diseases requires a better understanding of the molecular and cellular pathways regulating T cell function. Dr. Hongbo Chi is using a new genetic tool to study this molecular pathway in immune responses and autoimmune diseases with the long-term goal of translating the knowledge gained from these studies into innovative therapeutic strategies.

Article Author
Arthritis National Research Foundation

The Arthritis National Research Foundation's mission is to provide initial research funding to brilliant, investigative scientists with new ideas to cure arthritis and related autoimmune diseases. Writing articles about the patients affected and the science being done to find a cure shows why we need to come together to #CureArthritis!

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