Martin Kriegel, M.D.

Martin Kriegel, M.D.


Gene Therapy for Lupus
Martin Kriegel, M.D.

Yale University School of Medicine
New Haven, CT
T Cell-specific Deletion of GRAIL – the gene related to anergy in lymphocytes

One key mechanism to preserve normal immune response – called T cell anergy – is disturbed in SLE patients and lupus-prone mice. The molecular details of anergy are not fully understood. Dr. Martin Kriegel’s study will examine a particular enzyme in the anergy pathway called gene related to anergy in lymphocytes (GRAIL). He will genetically engineer a mouse so that GRAIL is not expressed, specifically in T cells, to study its role in the development of SLE and other systemic autoimmune diseases. In the long term, enzymes like GRAIL may provide novel therapeutic avenues for rheumatic diseases.

Article Author
Arthritis National Research Foundation

The Arthritis National Research Foundation's mission is to provide initial research funding to brilliant, investigative scientists with new ideas to cure arthritis and related autoimmune diseases. Writing articles about the patients affected and the science being done to find a cure shows why we need to come together to #CureArthritis!

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