Mei Chen, M.D., Ph.D.

Mei Chen, M.D., Ph.D.


Understanding Inflammatory Progression in RA


Mei Chen, M.D., Ph.D.

Brigham & Women’s Hospital
Boston, MA
The Mechanisms of LTB4-induced Migration and Invasion in Fibroblast-like Synoviocytes (FLS)

Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disease that primarily targets synovial tissues, which forms the joint lining and produces lubricating and cushioning synovial fluid. It is relatively common with a prevalence of approximately 1% in adults worldwide.
Although anti-Tumor Necrosis Factor (TNF) and anti-IL-1 antibodies are effective therapies for RA patients, subgroups of RA patients do not respond to these treatments. To create new therapies to fight this inflammation, the mechanisms by which inflammation occurs must be understood. Fibroblast-like synoviocytes (FLS), the major cellular populations in the synovial lining, directly contribute to inflammatory arthritis through aggressive invasion into the cartilage and bone. Dr. Chen’s lab has demonstrated a critical role of leukotriene B4 (LTB4), an inflammatory mediator, in inflammatory arthritic models. Dr. Chen’s project seeks to understand the role of LTB4 in synovial inflammation in the pathogenesis of inflammatory arthritis.
Defining these mechanisms in the mouse will permit focused exploration of similar mechanisms in humans. Ultimately, such work may eventually provide new therapeutic options for patients with rheumatoid arthritis.

Article Author
Arthritis National Research Foundation

The Arthritis National Research Foundation's mission is to provide initial research funding to brilliant, investigative scientists with new ideas to cure arthritis and related autoimmune diseases. Writing articles about the patients affected and the science being done to find a cure shows why we need to come together to #CureArthritis!

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