Nunzio Bottini, M.D.

Nunzio Bottini, M.D.


Enzyme Predisposes to Autoimmune Disorders
Nunzio Bottini, M.D.

University of Southern California

Los Angeles, CA
PTPN22: Enzymology of an Autoimmune-Predisposing Tyrosine Phosphate Variant

Bottini’s laboratory is studying an enzyme called lymphoid phosphatase, which acts as a critical gatekeeper of the activation of immune cells. Individuals carrying a particular genetic variant of this enzyme are predisposed to a variety of autoimmune diseases, including type 1 diabetes, lupus, and rheumatoid arthritis. In this research project, Dr. Bottini will examine the activity of this enzyme and the genetic variant to help clarify the mechanism of this enzyme in autoimmunity and validate it as a target for new drugs aimed at preventing and treating human autoimmune diseases.

Article Author
Arthritis National Research Foundation

The Arthritis National Research Foundation's mission is to provide initial research funding to brilliant, investigative scientists with new ideas to cure arthritis and related autoimmune diseases. Writing articles about the patients affected and the science being done to find a cure shows why we need to come together to #CureArthritis!

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