Alla Tsytsykova, Ph.D.
The Center for Blood Research (an affiliate of Harvard Medical School)
Tumor Necrosis Factor Alpha (TNF-alpha) is a protein responsible for inflammation and, ultimately, cartilage destruction in the joints of individuals with rheumatoid arthritis. Dr. Tsytsykova’s project will study how the TNF-alpha gene is activated in T-lymphoctyes, the cells in the synovial fluid of joints that secrete TNF-alpha. The knowledge gained from this study may potentially lead to the development of therapies that interrupt TNF-alpha gene expression in RA.