The following is a description of a study from one of the many researchers that our organization has funded.

Genetic Factors in Lupus

Amr Sawalha, M.D.
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma
CD40L overexpression in lupus T cells

Systemic lupus erythematosus (SLE or lupus) is a chronic, relapsing autoimmune disease that affects multiple organs including the skin, joints, lungs, kidneys and brain. The disease is at least nine times more common in females. There is evidence for both genetic and environmental factors implicated in the pathogenesis of lupus; however, the exact pathogenesis of the disease remains incompletely understood.

Using a mouse model, Dr. Sawalha will study a specific gene that is over expressed in the T regulatory white cells of female but not male mice. The goal of these studies is to provide new insights into mechanisms causing lupus, and identify new approaches to the treatment of this sometimes fatal disease.

You may return to the list of research that we have funded.
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