Adulthood obesity is known to be associated with risk for osteoarthritis (OA). Yet, it is currently unknown what influence childhood or early adulthood weight patterns may have on later risk for joint disease. Dr. Duren investigated the effects of lifelong fluctuations of body weight on the normal and pathological progression of aging joints. Early detection of causes of bone alteration and cartilage loss as a result of Dr. Duren’s research may provide an important link to later development of OA and contribute to future interventions in individuals at greatest risk.