The following is a description of a study from one of the many researchers that our organization has funded.

Arthritis and Growth in Children

Hulya Bukulmez, M.D.
Case Western Reserve University
Cleveland, Ohio
Does disruption of the C-type natriuretic peptide (CNP) signaling pathway cause cartilage degradation and growth retardation in juvenile rheumatoid arthritis?

Dr. Bukulmez is studying the effect of chronic arthritis on a child’s growth. The most dramatic negative effects are found in children with juvenile rheumatoid arthritis (JRA): destruction of growth plates in children often requires surgical correction. Dr. Bukulmez is studying the mechanisms of inflammation as they relate to growth delay in bones. Her study is at the molecular level with the goal of developing a new treatment for preventing growth delay or correcting the bone and cartilage damage seen during JRA and adult rheumatoid arthritis (RA).

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