The following is a description of a study from one of the many researchers that our organization has funded.

Insuring B Cell Tolerance

Julie Lang, Ph.D.
University of Colorado Health Sciences Center
Denver, Colorado
The role of CR2 in central and peripheral tolerance

A subset of white blood cells, known as B lymphocytes, is responsible for generating antibodies during an immune response to infection. In normal individuals, the immune system insures that antibodies and immune responses are not directed to self-tissues, a process known as “immune tolerance.” The development of autoantibodies associated with numerous autoimmune diseases, most notably lupus, involves a loss of this B cell tolerance. Dr. Lang’s studies will help elucidate the molecular mechanisms involved in the loss of B cell tolerance leading to autoantibody production, which, in turn, will be important in developing therapies designed to insure B cell tolerance.

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