The following is a description of a study from one of the many researchers that our organization has funded.

Reversing Fibrosis

Kemin Chen, M.D., Ph.D.
University of Missouri-Columbia
Columbia, Missouri
Role of Chemokines and matrix metalloproteinases in resolution vs fibrosis in a murine model of granulomatous experimental autoimmune thyroiditis (G-EAT): implications for pathology and treatment

Fibrosis is the cycle of damage-healing-scarring-damage, etc. in inflammatory disease. The functions of various proteins and peptides are to direct specific inflammatory cells to the diseased tissue and to regulate formation and breakdown of fibers in scars. Research has shown that fibrosis progresses in some mice, but other affected mice return to normal, suggesting that healing mechanisms exist to end inflammation and clear the scarring, thereby reversing fibrosis.

The results of Dr. Kemin Chen’s study will be 1) to determine if fibrosis derives from dysregulated proteins and peptides in the study, and 2) to design therapeutic strategies to inhibit development of fibrosis by blocking the specific proteins and peptides (chemokines and MMPs).

You may return to the list of research that we have funded.