Role of protein kinase R in TNF-alpha production
Kristine Phillips, M.D., Ph.D.
Brigham and Women’s Hospital (affiliated with Harvard Medical School)
Dr. Phillips’ study is evaluating how different levels of TNR-alpha protein are produced. Treatment of arthritis has been revolutionized by the use of biologic agents that inhibit the actions of tumor necrosis factor-alpha (TNF-a) protein. Dr. Phillips’ is seeking to establish the role of the molecules involved in the regulation of TNF-a protein production. Ultimately, the goal is to identify new targets for anti-inflammatory therapies.