The following is a description of a study from one of the many researchers that our organization has funded.

Bioactive protein may play role in cartilage degeneration

Lei Wei, Ph.D.
Brown Medical School/Rhode Island Hospital
Providence, Rhode Island
Grace Haussner Memorial Fellow

Inducible deletion of Ihh Prevents Osteoarthritic Cartilage Degeneration

Osteoarthritis affects over 27 million people in the United States but the pathogenesis of OA remains under active investigation. Recent evidence suggests that a bioactive protein within the joint called Indian hedgehog (Ihh) is involved. The study will provide insight into the mechanism of cartilage degeneration mediated by Ihh, and important data regarding the potential efficacy of Ihh-targeted therapies for treating osteoarthritis.

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