Bioactive protein may play role in cartilage degeneration
Inducible deletion of Ihh Prevents Osteoarthritic Cartilage Degeneration
Osteoarthritis affects over 27 million people in the United States but the pathogenesis of OA remains under active investigation. Recent evidence suggests that a bioactive protein within the joint called Indian hedgehog (Ihh) is involved. The study will provide insight into the mechanism of cartilage degeneration mediated by Ihh, and important data regarding the potential efficacy of Ihh-targeted therapies for treating osteoarthritis.