The following is a description of a study from one of the many researchers that our organization has funded.

Pathways of Inflammation in Lupus

Lihua Bao, M.D.
University of Chicago
Chicago, Illinois
Dissect the Roles of C3a and C5a in the Development of Experimental Lupus Nephritis

Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease that predominantly affects young women. While SLE can affect just about any organ system, the most severely affected is the kidney, often resulting in renal failure. In spite of the ever-growing knowledge about how the disease begins and progresses, treatment regimens for SLE contain potent, nonspecific immunosuppressive medications with a high incidence of side effects. “Non-specific” means that the entire immune system is suppressed, increasing the patient’s susceptibility to outside infections.

Dr. Bao’s study is designed to test a therapy of blocking specific cell receptors in the treatment of autoimmune diseases such as the kidney disease caused by lupus. Her study will also expand knowledge of the roles of innate and adaptive immunity and apoptosis (cell death) in the disease progression of SLE. Her study will encompass both genetic and pharmacological approaches to treat lupus.

You may return to the list of research that we have funded.
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