Autoantibodies to GPI in Rheumatoid Arthritis Pathogenesis.
Monica Schaller, Ph.D.
The Scripps Research Institute
La Jolla, California
Dr. Schaller is studying an enzyme present in all cells of the human body, GPI (glucose-6-phosphate isomerase). Preliminary studies indicate that anti-GPI antibodies, found in higher levels in the blood of patients with rheumatoid arthritis, may cause RA. This study will test this hypothesis as well as study GPI in depth in order to facilitate the testing of compounds to block the disease-causing anti-GPI antibodies, hopefully contributing to the reduction or prevention of RA symptoms in humans.