2010-2011
The following is a description of a study from one of the many researchers that our organization has funded.

Enzyme Predisposes to Autoimmune Disorders

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Nunzio Bottini, M.D.
University of Southern California
Los Angeles, California
PTPN22: Enzymology of an Autoimmune-Predisposing Tyrosine Phosphate Variant

Bottini’s laboratory is studying an enzyme called lymphoid phosphatase, which acts as a critical gatekeeper of the activation of immune cells. Individuals carrying a particular genetic variant of this enzyme are predisposed to a variety of autoimmune diseases, including type 1 diabetes, lupus, and rheumatoid arthritis. In this research project, Dr. Bottini will examine the activity of this enzyme and the genetic variant to help clarify the mechanism of this enzyme in autoimmunity and validate it as a target for new drugs aimed at preventing and treating human autoimmune diseases.

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