A novel modulator of neutrophil function in inflammatory arthritis

Neutrophils are immune cells that migrate into the joint cavity during inflammatory arthritis. Studies in mice confirm that neutrophils are absolutely necessary for the normal evolution of arthritis, but little is known about the mechanisms by which neutrophils reach the joint, what they do once they arrive, and how this can be manipulated therapeutically.

Dr. Nigrovic has found that a particular protein on the surface of mouse neutrophils appears to play a role in this process. He anticipates that these experiments will contribute to the understanding of the mechanisms by which neutrophils reach the inflamed joint, and potentially define a novel mechanism by which neutrophil recruitment can be targeted to treat inflammatory joint disease.