Role of NFFAT Proteins in DC154 Gene Regulation and Lupus
Randy Cron, M.D., Ph.D.
The Children’s Hospital of Philadelphia – University of Pennsylvania
Recent findings show that a protein, CD154, is abnormally expressed on the surface of certain white cells of lupus patients. While a therapy blocking the effect of CD154 has improved lupus in mice, it has not had the same effect on humans. Dr. Cron has found that one protein, NFAT, important to the expression of CD154, may be abnormally expressed in humans. They are studying the effect of a new inhibitor of NFAT proteins on CD154 expression in hopes of developing an alternative, potentially less toxic, therapy for lupus patients.