2008-2009
The following is a description of a study from one of the many researchers that our organization has funded.

New RA Therapy Explored: IL-27

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Shiva Shahrara, Ph.D.
Northwestern University
Chicago, Illinois
Recipient of The Sontag Foundation Fellow of the ANRF
The Role of IL-27 in Experimental Arthritis

IL-17 is a pro-inflammatory mediator that is expressed in rheumatoid arthritis (RA) joint tissue and joint fluid. IL-17 is produced by subset of white blood cells called TH-17 cells. TH-17 cells play an important role in initiation and progression of animal models of arthritis. Additionally, IL-27 is shown to suppress maturation of IL-17 producing cells. Therefore, in this proposal, Dr. Shahrara plans to inhibit maturation of TH-17 cells by over producing IL-27 in an animal model of arthritis and determining whether they can reduce inflammation, bone erosion and inflammatory mediators. Completion of this proposal will determine whether IL-27 can be utilized as a new therapeutic option for patients with RA.

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