Sucheta M. Vaingankar, Ph.D.
Veterans Medical Research Foundation, UCSD
San Diego, California
With aging and/or osteoarthritis, the cartilage in joints calcifies due to crystal deposits that directly provoke inflammation, pain and cartilage degeneration. The major mediator of these crystal deposits is a chemical inorganic pyrophosphate. Dr. Vaingankar’s study is aimed at understanding the mechanism of the calcification of cartilage and may lead to the identification of novel pyrophosphate-based therapies for treating osteoarthritis.