Xin Dong, Ph.D.
University of Pittsburgh School of Medicine
More than 80 percent of rheumatoid arthritis patients produce antibodies against their own immune system, called rheumatoid factors. It is believed that rheumatoid factor production by B cells is controlled by specific “antibody-reactive” T cells. Dr. Dong is studying the T cells thought to produce rheumatoid factors. This work may lead to the design of drugs or therapeutic strategies to inhibit these specific T cells from producing autoantibodies.