The following is a description of a study from one of the many researchers that our organization has funded.

Getting at the Root of Knee OA Pain

Xin Li, M.D., Ph.D
Rush University Medical Center
Chicago, Illinois
Analgesic effect of spinal micro-RNAs on symptomatic knee OA pain

Osteoarthritis (OA) affects more than100 million individuals worldwide and causes chronic and severe pain in knee joints. It is not clear what causes pain in OA, nor is there an effective way to relieve the pain. Understanding mechanisms of pain caused by OA is essential to finding more effective treatments.

Micro-RNAs are small RNA molecules that regulate gene expression. Using established knee joint OA pain animal models and molecular biological methodology, Dr. Li is studying the links between selected micro-RNAs and knee OA pain. This study seeks to identify the mechanisms responsible for OA-associated knee joint pain, then use targeted inactivation of selected micro-RNAs to lessen pain symptoms.

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