Shiguang Yu, Ph.D.

Shiguang Yu, Ph.D.


Autoimmune Disease Inhibited by T Regulatory Cells

Shiguang Yu, Ph.D.

University of Missouri
Columbia, MO
Mechanisms by which CD4 and CD25 Regulatory T Cells inhibit Autoimmune Diseases in the Absence of B Cells

Autoimmune diseases arise when the immune system reacts against self tissues or organs. Low activity or dysfunction of T regulatory cells can cause autoimmune diseases. Dr. Yu’s recent work demonstrated that T regulatory cells make B cell deficient mice resistant to autoimmune disease. The goal of this study is to test whether the depletion of B cells inhibits autoimmune disease by increasing T regulatory cell activity. The information derived from this study will provide clues for modulating the activity and number of T regulatory cells to inhibit autoimmune diseases.

Article Author
Arthritis National Research Foundation

The Arthritis National Research Foundation's mission is to provide initial research funding to brilliant, investigative scientists with new ideas to cure arthritis and related autoimmune diseases. Writing articles about the patients affected and the science being done to find a cure shows why we need to come together to #CureArthritis!

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