Shiva Shahrara, Ph.D.

Shiva Shahrara, Ph.D.

2008-2009

New RA Therapy Explored: IL-27
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Shiva Shahrara, Ph.D.

Northwestern University
Chicago, IL
Recipient of The Sontag Foundation Fellow of the ANRF
The Role of IL-27 in Experimental Arthritis

IL-17 is a pro-inflammatory mediator that is expressed in rheumatoid arthritis (RA) joint tissue and joint fluid. IL-17 is produced by subset of white blood cells called TH-17 cells. TH-17 cells play an important role in initiation and progression of animal models of arthritis. Additionally, IL-27 is shown to suppress maturation of IL-17 producing cells. Therefore, in this proposal, Dr. Shahrara plans to inhibit maturation of TH-17 cells by over producing IL-27 in an animal model of arthritis and determining whether they can reduce inflammation, bone erosion and inflammatory mediators. Completion of this proposal will determine whether IL-27 can be utilized as a new therapeutic option for patients with RA.

ANRF
Article Author
Arthritis National Research Foundation
arthritisresearch@curearthritis.org

The Arthritis National Research Foundation's mission is to provide initial research funding to brilliant, investigative scientists with new ideas to cure arthritis and related autoimmune diseases. Writing articles about the patients affected and the science being done to find a cure shows why we need to come together to #CureArthritis!

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