Sougata Karmakar, Ph.D.

Sougata Karmakar, Ph.D.


Understanding Bone Loss in RA
Sougata Karmakar, Ph.D.

University of Massachusetts Medical School
Worcester, MA
The role of BMP3 in the pathogenesis of focal articular bone loss in inflammatory arthritis

Rheumatoid arthritis (RA) is a chronic, debilitating disease that affects the joints in patients and may result in bone loss. The structural integrity of bone is maintained by the coordinated actions of two cell types, the bone-forming osteoblast and the bone-resorbing osteoclast. In rheumatoid arthritis (RA), there is an imbalance in the activities of these two cells, resulting in bone loss leading to joint deformity and pain.

Dr. Karmakar will study bone morphogenetic protein (BMP) in arthritic mice, hoping to demonstrate that an antagonist of BMP inhibits osteoblast maturation and function at bone erosion sites in RA joints, resulting in impaired bone formation. Understanding these mechanisms will allow for the identification of novel targets to augment bone formation at erosion sites, a necessary step to preserve joint function in RA.

Dr. Karmakar has been honored as The Sontag Foundation Fellow for 2007-2008, for excellence in research related to rheumatoid arthritis.

Article Author
Arthritis National Research Foundation

The Arthritis National Research Foundation's mission is to provide initial research funding to brilliant, investigative scientists with new ideas to cure arthritis and related autoimmune diseases. Writing articles about the patients affected and the science being done to find a cure shows why we need to come together to #CureArthritis!

No Comments

Sorry, the comment form is closed at this time.