Sougata Karmakar, Ph.D.

Sougata Karmakar, Ph.D.

2008-2009

A Clue to Bone Loss in Rheumatoid Arthritis
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Sougata Karmakar, Ph.D.

University of Massachusetts
Worcester, MA
The role of BMP3 in the pathogenesis of focal articular bone loss in inflammatory arthritis

Rheumatoid arthritis (RA) is a chronic, debilitating disease that affects the joints in patients and may result in bone loss. Specialized cells called osteoclasts are responsible for the removal of bone in bone erosions, leading ultimately to impaired joint function. In addition, these erosive bone lesions are not typically “repaired” over time by bone forming cells called osteoblasts, thereby tipping the balance towards increased bone loss over time.

In RA, osteoblast-mediated bone formation may be compromised at local erosive sites. Several soluble factors are known to influence the maturation and function of osteoblasts. Understanding the mechanisms regulating osteoblast maturation and function in RA may allow for the identification of novel targets in the molecular pathway to augment bone formation at erosion sites, an important step toward preserving joint architecture in RA.

ANRF
Article Author
Arthritis National Research Foundation
arthritisresearch@curearthritis.org

The Arthritis National Research Foundation's mission is to provide initial research funding to brilliant, investigative scientists with new ideas to cure arthritis and related autoimmune diseases. Writing articles about the patients affected and the science being done to find a cure shows why we need to come together to #CureArthritis!

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